Rubinsztajn Renata, Kumor Marta, Byśkiniewicz Krzysztof, Bielicki Piotr, Chazan Ryszarda
Katedra i Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii AM w Warszawie.
Pol Arch Med Wewn. 2005 Jun;113(6):544-51.
Hypertension, coronary heart diseases, obesity, diabetes mellitus are often present in patients with obstructive sleep apnea (OSA). The aim of the study was to estimate the serum leptin concentration and sympathetic activity in patients with obstructive sleep apnea and in control group.
51 persons (F6, M45) were included into the study. The control group (GK) consisted of 15 snoring person (15 M) in the age x = 44.19 +/- 14.60, study group (GB) consisted of 36 patients with OSA (6F, 30M) in the age 5 1.47 +/- 8.95 years.
Leptin was measured by RIA methods using the HUMAN LEPTIN RIA KIT (LINCO Research, Inc).: adrenaline and noradrenaline were measured in the serum by HPLC methods (BIO-RAD).
The serum concentrations of leptin (ng/mL), adrenaline and noradrenaline (pg/mL) in patients with OSA compared with control group were respectively 15.55 +/- 11.26 : 61.2 +/- 27.4: 523.2 +/- 165.1 vs 10.34+/- 6.86 : 47.7 +/- 27.3: 447.9 +/- 102.6. There was positive significant correlation between leptin concentration and BMI (r = 0,34) and serum leptin and adrenalin concentration (r = 0,34). The serum leptin concentration was significantly higher in the female group. In the male group there was tendency to increase leptin concentration together with degree of OSA grade estimated by AHI and AHI <50 leptin concentration 12.23+/- 6.96 ng/mL vs AHI>50 and leptin concentration 13.35 +/- 3.54ng/ml.
阻塞性睡眠呼吸暂停（OSA）患者常伴有高血压、冠心病、肥胖症和糖尿病。本研究旨在评估阻塞性睡眠呼吸暂停患者及对照组的血清瘦素浓度和交感神经活性。
51人（女性6人，男性45人）纳入本研究。对照组（GK）由15名打鼾者（均为男性）组成，年龄x = 44.19 ± 14.60岁，研究组（GB）由36例阻塞性睡眠呼吸暂停患者（女性6人，男性30人）组成，年龄51.47 ± 8.95岁。
采用人瘦素放射免疫分析试剂盒（LINCO Research公司）通过放射免疫分析方法测定瘦素；采用高效液相色谱法（BIO - RAD）测定血清中的肾上腺素和去甲肾上腺素。
与对照组相比，阻塞性睡眠呼吸暂停患者血清瘦素浓度（ng/mL）、肾上腺素和去甲肾上腺素浓度（pg/mL）分别为15.55 ± 11.26 : 61.2 ± 27.4 : 523.2 ± 165.1，而对照组为10.34 ± 6.86 : 47.7 ± 27.3 : 447.9 ± 102.6。瘦素浓度与体重指数（r = 0.34）以及血清瘦素与肾上腺素浓度之间存在显著正相关（r = 0.34）。女性组血清瘦素浓度显著更高。在男性组中，随着通过呼吸暂停低通气指数（AHI）评估的阻塞性睡眠呼吸暂停严重程度增加，瘦素浓度有升高趋势，AHI < 50时瘦素浓度为12.23 ± 6.96 ng/mL，AHI > 50时瘦素浓度为13.35 ± 3.54 ng/mL。
