一名患者同时患有乳糜泻（CD）、溃疡性结肠炎（UC）和原发性硬化性胆管炎（PSC）：一项家族研究。

Celiac disease (CD), ulcerative colitis (UC), and primary sclerosing cholangitis (PSC) in one patient: a family study.

作者信息

Cadahía V, Rodrigo L, Fuentes D, Riestra S, de Francisco R, Fernández M

机构信息

Service of Digestive Diseases, Hospital Universitario Central de Asturias, Oviedo, Spain.

出版信息

Rev Esp Enferm Dig. 2005 Dec;97(12):907-13. doi: 10.4321/s1130-01082005001200007.

DOI:10.4321/s1130-01082005001200007

PMID:16454610

Abstract

We discuss the case of a 17-year-old male who at the age of 7 was diagnosed with celiac disease (CD) together with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). The patient was treated with gluten-free diet and immunosuppressive drugs (azathioprine), and currently remains asymptomatic. The patient's younger, 12-year-old sister was diagnosed with CD when she was 1.5 years old, and at 7 years she developed type-I diabetes mellitus, which was difficult to control. A family study was made, and both parents were found to be affected with silent CD. All were DQ2 (+). In relation to the case and family study, we provide a series of comments related to CD and its complications.

摘要

我们讨论了一名17岁男性的病例，该男性在7岁时被诊断患有乳糜泻（CD），同时患有溃疡性结肠炎（UC）和原发性硬化性胆管炎（PSC）。患者接受了无麸质饮食和免疫抑制药物（硫唑嘌呤）治疗，目前仍无症状。患者12岁的妹妹在1.5岁时被诊断患有CD，7岁时患了难以控制的I型糖尿病。进行了一项家庭研究，发现父母双方均患有隐性CD。所有人的DQ2均为阳性。针对该病例和家庭研究，我们提供了一系列与CD及其并发症相关的评论。