Wang W, Ma R C
Department of Physiology, Anhui Medical University, Hefei.
Sheng Li Xue Bao. 1991 Feb;43(1):1-7.
By means of intracellular recording technique, it was observed that: (1) Application of serotonin (5-HT) caused in a portion of the neurons of the guinea pig inferior mesenteric ganglia (IMG) a slow depolarization similar to non-cholinergic late slow excitatory postsynaptic potential (ls-EPSP). (2) Prolonged superfusion of 5-HT markedly suppressed the ls-EPSP in 5-HT sensitive neurons. (3) The ls-EPSP elicited in 5-HT sensitive neurons as well as the 5-HT depolarization could be enhanced by fluoxetine 5-HT reuptake inhibitor; In contrast, the ls-EPSP of 5-HT insensitive neurons was not appreciably changed by this drug. (4) Pretreating the guinea pigs with para-chlorophenylalanine (PCPA), a 5-HT biosynthesis inhibitor, markedly reduced the occurrence rate and amplitude of ls-EPSP. These results indicate that ls-EPSP of the guinea pig IMG is possibly mediated by several transmitters including 5-HT.
（1）应用血清素（5-羟色胺，5-HT）可使豚鼠肠系膜下神经节（IMG）的一部分神经元产生缓慢去极化，类似于非胆碱能迟发性慢兴奋性突触后电位（ls-EPSP）。（2）5-HT的长时间灌流显著抑制了5-HT敏感神经元中的ls-EPSP。（3）5-HT再摄取抑制剂氟西汀可增强5-HT敏感神经元中诱发的ls-EPSP以及5-HT去极化；相反，该药物对5-HT不敏感神经元的ls-EPSP没有明显影响。（4）用5-HT生物合成抑制剂对氯苯丙氨酸（PCPA）预处理豚鼠，可显著降低ls-EPSP的发生率和幅度。这些结果表明，豚鼠IMG的ls-EPSP可能由包括5-HT在内的几种神经递质介导。
