散发性戊型肝炎与甲型肝炎的流行病学及临床特征比较
Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A.
作者信息
Chau Tai Nin, Lai Sik To, Tse Cyndy, Ng Tak Keung, Leung Vincent King Sun, Lim Wilina, Ng Mun Hon
机构信息
Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China.
出版信息
Am J Gastroenterol. 2006 Feb;101(2):292-6. doi: 10.1111/j.1572-0241.2006.00416.x.
OBJECTIVES
To compare the epidemiology and clinical features of two enterically transmitted hepatitis, namely hepatitis E and hepatitis A.
METHODS
We analyzed clinical features and risk factors of 105 cases of hepatitis A and 24 cases of hepatitis E admitted in 2002. All patients were tested positive for IgM antibody against either hepatitis A virus (HAV) or hepatitis E virus (HEV), and all patients were tested to be negative for IgM anti-HBV or IgG anti-HCV.
RESULTS
Hepatitis A patients were significantly younger (median age = 27 yr) and most had a recent history of shellfish consumption, whereas hepatitis E patients were older (median age = 53 yr) and most had a recent travel history. Whereas hepatitis A was milder and recovery was uneventful, hepatitis E was more severe, associated with significant mortality and frequently complicated by protracted coagulopathy and cholestasis.
CONCLUSIONS
Hepatitis E is a more severe disease entity as compared with hepatitis A and significant proportion of them are imported cases from an endemic area.
目的
比较两种经肠道传播的肝炎，即戊型肝炎和甲型肝炎的流行病学及临床特征。
方法
我们分析了2002年收治的105例甲型肝炎患者和24例戊型肝炎患者的临床特征及危险因素。所有患者甲型肝炎病毒（HAV）或戊型肝炎病毒（HEV）IgM抗体检测均为阳性，且所有患者HBV IgM抗体或HCV IgG抗体检测均为阴性。
结果
甲型肝炎患者明显更年轻（中位年龄 = 27岁），且大多数近期有食用贝类的病史，而戊型肝炎患者年龄较大（中位年龄 = 53岁），且大多数近期有旅行史。甲型肝炎病情较轻，恢复顺利，而戊型肝炎病情更严重，伴有显著死亡率，且常并发迁延性凝血病和胆汁淤积。
结论
与甲型肝炎相比，戊型肝炎是一种更严重的疾病实体，且其中相当一部分是来自流行地区的输入性病例。
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