Blake J, Li C H
J Med Chem. 1975 Apr;18(4):423-6. doi: 10.1021/jm00238a020.
Three biologically active peptides, [9-beta-(1-naphthyl)alanine]-ACTH-(1-19), [9-Ni-formyltryptophanl-ACTH-1(1-19), and (8-lysine,9-phenylalaninel-ACTH-1(1-9), have been synthesized by the solid-phase method. All of the synthetic peptides showed diminished biological activity compared to ACTH-(1-19). It was also shown that the steroidogenic and lipolytic activities of ACTH-(1-19) were not inhibited by [8-lysine,.-phenylalanine]-ACTH-(1-19).
三种生物活性肽，即[9-β-(1-萘基)丙氨酸]-促肾上腺皮质激素-(1-19)、[9-镍甲酰色氨酸]-促肾上腺皮质激素-1(1-19)和(8-赖氨酸,9-苯丙氨酸)-促肾上腺皮质激素-1(1-9)，已通过固相法合成。与促肾上腺皮质激素-(1-19)相比，所有合成肽的生物活性均降低。还表明，(8-赖氨酸,9-苯丙氨酸)-促肾上腺皮质激素-(1-19)不会抑制促肾上腺皮质激素-(1-19)的类固醇生成和脂解活性。
