基于(-)-dysiherbaine结构的离子型谷氨酸受体（iGluR）配体支架的设计、合成及生物学评价
Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine.
作者信息
Cohen Jamie L, Limon Agenor, Miledi Ricardo, Chamberlin A Richard
机构信息
Department of Chemistry, University of California at Irvine, Irvine, CA 92697, USA.
出版信息
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2189-94. doi: 10.1016/j.bmcl.2006.01.047. Epub 2006 Feb 7.
PMID:16455241
Abstract
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (-)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist.
摘要
本文描述了四种与几种含谷氨酸的天然产物（包括(-)-dysiherbaine）结构相关的2,2-二取代二氢苯并呋喃的设计与合成。对这些类似物的生物学评估表明，其中一种是KA受体拮抗剂，另一种是NMDA受体激动剂。
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