Megwalu Uchechukwu C, Finnell Joshua E, Piccirillo Jay F
Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Otolaryngol Head Neck Surg. 2006 Feb;134(2):210-3. doi: 10.1016/j.otohns.2005.10.007.
To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep.
Prospective open-label study of 24 patients with tinnitus. The patients took 3 mg of melatonin per day for 4 weeks, followed by 4 weeks of observation. The Tinnitus Handicap Inventory (THI) and the Pittsburgh Sleep Quality Index (PSQI) were administered.
The mean THI score decreased significantly between weeks 0 and 4, and between weeks 0 and 8. The mean PSQI significantly decreased between weeks 0 and 4 (P < 0.0001), and between weeks 0 and 8 (P = 0.0003). The change in PSQI was significantly associated with the change in THI between weeks 0 and 4. The change in PSQI was not significantly associated with the change in THI between weeks 0 and 8. The change in the PSQI in the first 4 weeks was associated with the initial PSQI. There was no association between the initial THI and the change in the THI in the first 4 weeks.
Melatonin use is associated with improvement of tinnitus and sleep. There was an association between the amount of improvement in sleep and tinnitus. The impact of melatonin on sleep was greatest among patients with the worst sleep quality, but its impact on tinnitus was not associated with the severity of the tinnitus.
Melatonin may be a safe treatment for patients with idiopathic tinnitus, especially those with sleep disturbance due to tinnitus.
确定褪黑素是否能改善耳鸣，以及这种改善是否与睡眠改善有关。
对24例耳鸣患者进行前瞻性开放标签研究。患者每天服用3毫克褪黑素，持续4周，随后进行4周观察。采用耳鸣障碍量表（THI）和匹兹堡睡眠质量指数（PSQI）进行评估。
在第0周和第4周之间以及第0周和第8周之间，平均THI评分显著降低。在第0周和第4周之间（P<0.0001）以及第0周和第8周之间（P = 0.0003），平均PSQI显著降低。在第0周和第4周之间，PSQI的变化与THI的变化显著相关。在第0周和第8周之间，PSQI的变化与THI的变化无显著相关性。前4周PSQI的变化与初始PSQI相关。初始THI与前4周THI的变化之间无关联。
使用褪黑素与耳鸣和睡眠的改善有关。睡眠改善量与耳鸣改善之间存在关联。褪黑素对睡眠质量最差的患者影响最大，但其对耳鸣的影响与耳鸣严重程度无关。
褪黑素可能是特发性耳鸣患者，尤其是因耳鸣导致睡眠障碍患者的一种安全治疗方法。
