Tei指数显示低剂量蒽环类化疗对左、右心室功能有不同影响。
The Tei index identifies a differential effect on left and right ventricular function with low-dose anthracycline chemotherapy.
作者信息
Belham Mark, Kruger Anton, Pritchard Colin
机构信息
Department of Cardiology, Royal Cornwall Hospital, Cornwall, United Kingdom.
出版信息
J Am Soc Echocardiogr. 2006 Feb;19(2):206-10. doi: 10.1016/j.echo.2005.08.018.
OBJECTIVE
We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes.
METHODS
A total of 23 patients (mean age 48 +/- 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function.
RESULTS
Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 +/- 0.12 vs 0.46 +/- 0.16, P = .02). There was no significant change in the RV Tei index (0.19 +/- 0.10 vs 0.20 +/- 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 +/- 0.13 vs 0.01 +/- 0.09, P = .044).
CONCLUSIONS
Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function.
目的
我们试图研究含低剂量蒽环类药物的化疗方案对左心室（LV）和右心室（RV）功能的相对影响。
方法
共有23例患者（平均年龄48±20岁）在给予任何蒽环类药物之前以及给予低剂量蒽环类药物（阿霉素50 - 125 mg/m²）之后接受了超声心动图检查。采用Tei指数比较对RV和LV功能的相对影响。
结果
给予蒽环类药物与LV Tei指数增加显著相关（0.38±0.12对0.46±0.16，P = 0.02）。RV Tei指数无显著变化（0.19±0.10对0.20±0.10，P = 0.72）。比较对整体LV和RV功能的相对影响，LV Tei的变化显著大于RV Tei的变化（0.07±0.13对0.01±0.09，P = 0.044）。
结论
给予低剂量蒽环类药物对LV功能有显著负面影响，但不影响RV功能。
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