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[PI3K-AKT-mTOR通路抑制剂]

[PI3K-AKT-mTOR pathway inhibitors].

作者信息

Cortot Alexis, Armand Jean-Pierre, Soria Jean-Charles

机构信息

Département de médecine, Institut Gustave-Roussy, 39, rue Camille-Desmoulin, 94805 Villejuif.

出版信息

Bull Cancer. 2006 Jan;93(1):19-26.

PMID:16455502
Abstract

Molecular targeted agents have enlarged the armamentarium of anti-cancer therapies. Along with the success of some anti-growth factor receptors, signal transduction inhibitors represent a promising anti-cancer strategy. The PI3K-AKT-mTOR pathway is a key pathway frequently altered in cancer cells. This manuscript provides an overview of the PI3K-AKT-mTOR pathway and its targeting in human malignancies. A focus is delivered for mTOR inhibitors.

摘要

分子靶向药物扩大了抗癌治疗的手段。随着一些抗生长因子受体药物取得成功，信号转导抑制剂成为一种有前景的抗癌策略。PI3K-AKT-mTOR通路是癌细胞中经常发生改变的关键通路。本文综述了PI3K-AKT-mTOR通路及其在人类恶性肿瘤中的靶向作用。重点介绍了mTOR抑制剂。

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