在耐甲氧西林金黄色葡萄球菌菌血症和骨髓炎治疗期间出现临床耐达托霉素金黄色葡萄球菌分离株。

Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis.

作者信息

Marty Francisco M, Yeh Wendy W, Wennersten Christine B, Venkataraman Lata, Albano Esperanza, Alyea Edwin P, Gold Howard S, Baden Lindsey R, Pillai Satish K

机构信息

Division of Infectious Diseases, Brigham & Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115, USA.

出版信息

J Clin Microbiol. 2006 Feb;44(2):595-7. doi: 10.1128/JCM.44.2.595-597.2006.

DOI:10.1128/JCM.44.2.595-597.2006

PMID:16455920

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1392688/

Abstract

The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.

摘要

在耐甲氧西林金黄色葡萄球菌菌血症和可能的椎体骨髓炎治疗期间，出现了一株临床对达托霉素耐药的金黄色葡萄球菌分离株。通过脉冲场凝胶电泳分析，该突破性分离株与治疗前对达托霉素敏感的分离株无法区分。通过最低抑菌浓度（MIC）和时间杀菌曲线分析证实了对达托霉素不敏感。