Marty Francisco M, Yeh Wendy W, Wennersten Christine B, Venkataraman Lata, Albano Esperanza, Alyea Edwin P, Gold Howard S, Baden Lindsey R, Pillai Satish K
Division of Infectious Diseases, Brigham & Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115, USA.
J Clin Microbiol. 2006 Feb;44(2):595-7. doi: 10.1128/JCM.44.2.595-597.2006.
The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.
在耐甲氧西林金黄色葡萄球菌菌血症和可能的椎体骨髓炎治疗期间,出现了一株临床对达托霉素耐药的金黄色葡萄球菌分离株。通过脉冲场凝胶电泳分析,该突破性分离株与治疗前对达托霉素敏感的分离株无法区分。通过最低抑菌浓度(MIC)和时间杀菌曲线分析证实了对达托霉素不敏感。