Suppr超能文献

口腔梭形细胞脂肪瘤

Spindle cell lipoma of the oral cavity.

作者信息

Billings Steven D, Henley John D, Summerlin Don-John, Vakili Saeed, Tomich Charles E

机构信息

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

出版信息

Am J Dermatopathol. 2006 Feb;28(1):28-31. doi: 10.1097/01.dad.0000189615.13641.4b.

Abstract

Spindle cell lipoma is typically seen in the neck/trunk region of middle-aged and older men. Rare cases of oral spindle cell lipoma have been reported. An entity described as myxoid lipoma of the oral cavity has rarely been reported but appears to be more properly classified as spindle cell lipoma. We describe the largest series yet of oral spindle cell lipoma involving the tongue (4), buccal mucosa (1), floor of mouth (1), and lip (1). The patients (3M; 4F) ranged from 31 to 88 years old. All presented with mass lesions. All were circumscribed and composed of mature adipocytes admixed with bland spindled cells. In two cases the adipocytes appeared atrophic, imparting a pseudo-lipoblastic appearance. No true lipoblasts were seen and none had the characteristic vasculature of a myxoid liposarcoma or the characteristic hyperchromatic cells of well-differentiated liposarcoma. The stromal background of all cases contained characteristic wiry collagen and myxoid ground substance. The myxoid ground substance was prominent in four cases. Immunohistochemical stains for CD34 highlighted the bland spindle cells in all cases. The combination of the histologic features and the immunoreactivity for CD34 confirmed the diagnosis. Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors.

摘要

梭形细胞脂肪瘤通常见于中老年男性的颈部/躯干区域。口腔梭形细胞脂肪瘤的罕见病例已有报道。一种被描述为口腔黏液样脂肪瘤的病变很少被报道,但似乎更应归类为梭形细胞脂肪瘤。我们描述了迄今为止最大系列的累及舌部(4例)、颊黏膜(1例)、口底(1例)和唇部(1例)的口腔梭形细胞脂肪瘤。患者年龄在31至88岁之间(3名男性;4名女性)。所有患者均表现为肿块病变。所有病变均边界清晰,由成熟脂肪细胞与温和的梭形细胞混合组成。在两例中,脂肪细胞出现萎缩,呈现假脂肪母细胞样外观。未见真正的脂肪母细胞,且均无黏液样脂肪肉瘤的特征性血管或高分化脂肪肉瘤的特征性深染细胞。所有病例的间质背景均含有特征性的细纤维状胶原和黏液样基质。黏液样基质在4例中较为突出。CD34免疫组化染色在所有病例中均突出显示了温和的梭形细胞。组织学特征与CD34免疫反应性相结合证实了诊断。在口腔间叶性肿瘤的鉴别诊断中应考虑梭形细胞脂肪瘤。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验