Pozler Oldrich, Maly Jan, Bonova Oldriska, Dedek Petr, Frühauf Pavel, Havlickova Alena, Janatova Tatiana, Jimramovsky Frantisek, Klimova Lenka, Klusacek Dalibor, Kocourkova Dana, Kolek Antonin, Kotalova Radka, Marx David, Nevoral Jiri, Petro Radim, Petru Ondrej, Plasilova Ivana, Seidl Zbynek, Sekyrova Ivana, Semendak Norbert, Schreierova Irena, Stanek Jan, Sykora Josef, Sulakova Astrid, Toukalkova Lenka, Travnickova Radka, Volf Vladimir, Zahradnicek Lubomir, Zenisková Ivana
Department of Pediatrics, Charles University Teaching Hospital, 500-05 Hradec Kralove, Czech Republic.
J Pediatr Gastroenterol Nutr. 2006 Feb;42(2):186-9. doi: 10.1097/01.mpg.0000189328.47150.bc.
The aim of this study was to assess the pediatric population that suffered from inflammatory bowel disease (IBD) in the Czech Republic and to determine the incidence of Crohn disease (CD) in children up to 15 years age between 1990 and 2001.
Diagnostic criteria for CD, ulcerative colitis (UC), and indeterminate colitis (IC) were defined. Medical records provided a source of basic information about the children. A standardized protocol was filled out and sent to the coordinator of the study. All protocols were checked to see whether the data corresponded to the defined criteria and then were processed further. The study was retrospective in character for the years 1990 to 1999 and prospective for the years 2000 and 2001.
Diagnostic criteria were met in 470 patients with IBD; 201 of them turned 18 years old during the study period. CD was diagnosed in 223 patients. The incidence of CD in children up to 15 years of age increased from 0.25/100,000 in 1990 to 1.25/100,000 in 2001. Eighty-two percent of children with CD were treated with aminosalicylates in combination with corticosteroids; 29% of patients received azathioprine. Severe growth retardation was recorded in 6.4% of adolescents with CD at the age of 18. UC was diagnosed in 202 patients. Therapy with aminosalicylates only was sufficient for control of the disease in 23% patients; 68% children were treated with corticosteroids, 15 of them (23% of the whole group) received additional azathioprine. Criteria for IC were met in 9.8% of all patients with IBD.
This study confirmed an increase in incidence of CD in children younger than 15 years in the Czech Republic.
本研究的目的是评估捷克共和国患有炎症性肠病（IBD）的儿科人群，并确定1990年至2001年间15岁以下儿童克罗恩病（CD）的发病率。
定义了CD、溃疡性结肠炎（UC）和不确定性结肠炎（IC）的诊断标准。医疗记录提供了有关儿童的基本信息来源。填写一份标准化方案并发送给研究协调员。检查所有方案以查看数据是否符合定义的标准，然后进一步处理。该研究在1990年至1999年期间为回顾性研究，在2000年和2001年为前瞻性研究。
470例IBD患者符合诊断标准；其中201人在研究期间年满18岁。223例患者被诊断为CD。15岁以下儿童CD的发病率从1990年的0.25/10万增加到2001年的1.25/10万。82%的CD儿童接受了氨基水杨酸酯与皮质类固醇联合治疗；29%的患者接受了硫唑嘌呤治疗。18岁的CD青少年中有6.4%记录有严重生长发育迟缓。202例患者被诊断为UC。仅用氨基水杨酸酯治疗足以控制23%患者的疾病；68%的儿童接受了皮质类固醇治疗，其中15人（占整个组的23%）接受了额外的硫唑嘌呤治疗。所有IBD患者中有9.8%符合IC标准。
本研究证实捷克共和国15岁以下儿童CD的发病率有所增加。
