Department of Pediatrics, University Hospital Brno.
Faculty of Medicine, Masaryk University.
J Pediatr Gastroenterol Nutr. 2020 May;70(5):586-592. doi: 10.1097/MPG.0000000000002660.
Inflammatory bowel disease (IBD) is today a global disease, the incidence of which is growing in the pediatric population. This prospective study aims to decipher IBD incidence and its trend in a pediatric population through 16 years in the South Moravian Region of the Czech Republic.
We evaluated data concerning 358 pediatric patients with newly diagnosed IBD at University Hospital Brno, which is a gastroenterology center for the entire pediatric population (0-18 years) and cares for all pediatric IBD patients in the South Moravian Region (1,187,667 inhabitants).
The study encompassed 3,488,907 children during 16 years. We diagnosed 192 children (53.6%) with Crohn disease (CD), 123 (34.4%) with ulcerative colitis (UC), and 43 (12.0%) with IBD-unclassified (IBD-U). The incidence of IBD increased from 3.8 (CD 2.9, UC 0.9, and IBD-U 0.0) per 100 000/year in 2002 to 14.7 (CD 9.8, UC 4.0, and IBD-U 0.9) per 100,000/year in 2017 (P < 0.001). The overall IBD incidence per 100,000/year was 9.8 (95% confidence interval [CI]: 8.8--10.9). Constituent incidences per 100,000/year were CD 5.2 (95% CI: 4.5--6.0), UC 3.4 (95% CI: 2.8--4.0), and IBD-U 1.2 (95% CI: 0.9--1.6). IBD incidence was projected to reach 18.9 per 100,000/year in 2022.
The overall incidence of pediatric IBD in the Czech Republic is increasing, and especially that of CD, whereas trends in UC and IBD-U appear to be constant. These data highlight the need to identify risk factors involved in the rising incidence of IBD.
炎症性肠病（IBD）如今是一种全球性疾病，其在儿科人群中的发病率正在上升。本前瞻性研究旨在通过捷克共和国南摩拉维亚地区 16 年的数据来阐明儿科人群中 IBD 的发病率及其趋势。
我们评估了布尔诺大学医院新诊断为 IBD 的 358 名儿科患者的数据，该医院是整个儿科人群（0-18 岁）的胃肠病学中心，并为南摩拉维亚地区（1187667 名居民）的所有儿科 IBD 患者提供护理。
该研究涵盖了 16 年内的 3488907 名儿童。我们诊断出 192 名（53.6%）患有克罗恩病（CD），123 名（34.4%）患有溃疡性结肠炎（UC），43 名（12.0%）患有未分类 IBD（IBD-U）。IBD 的发病率从 2002 年的每 10 万人 3.8 例（CD 2.9 例，UC 0.9 例，IBD-U 0.0 例）增加到 2017 年的每 10 万人 14.7 例（CD 9.8 例，UC 4.0 例，IBD-U 0.9 例）（P<0.001）。每 10 万人的总体 IBD 发病率为 9.8（95%置信区间[CI]：8.8-10.9）。每 10 万人的发病率分别为 CD 5.2（95%CI：4.5-6.0）、UC 3.4（95%CI：2.8-4.0）和 IBD-U 1.2（95%CI：0.9-1.6）。预计到 2022 年，儿科 IBD 的发病率将达到每 10 万人 18.9 例。
捷克共和国儿科 IBD 的总体发病率正在上升，尤其是 CD 的发病率，而 UC 和 IBD-U 的趋势似乎保持不变。这些数据突出表明，需要确定与 IBD 发病率上升相关的风险因素。
