Weiss J M, Sundar S K, Cierpial M A, Ritchie J C
Duke University Medical Center, Department of Psychiatry, Durham, NC 27710.
Eur J Pharmacol. 1991 Jan 3;192(1):177-9. doi: 10.1016/0014-2999(91)90087-7.
Interleukin-1 (IL-1) in the brain stimulates the pituitary-adrenal axis and markedly suppresses cellular immune responses. alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects. In that IL-1 has been shown to promote production of alpha-MSH, these results suggest that actions of IL-1 in brain are under negative feedback control and, consequently, that the effects of this cytokine in brain are of biological significance.
大脑中的白细胞介素-1（IL-1）刺激垂体-肾上腺轴，并显著抑制细胞免疫反应。与IL-1同时引入脑室系统的α-黑素细胞刺激素（α-MSH）以剂量依赖的方式阻断了IL-1的这些作用，10 ng的α-MSH完全阻断了血浆促肾上腺皮质激素（ACTH）和皮质酮的升高以及由一定剂量（100 pg）IL-1所产生的自然杀伤（NK）细胞活性的抑制，否则该剂量的IL-1会产生最大效应。鉴于IL-1已被证明可促进α-MSH的产生，这些结果表明大脑中IL-1的作用受到负反馈控制，因此，这种细胞因子在大脑中的作用具有生物学意义。
