Kettunen Mikko I, Gröhn Olli H J
Department of Biomedical NMR and National Bio-NMR Facility, A.I.Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
Curr Gene Ther. 2005 Dec;5(6):685-96. doi: 10.2174/156652305774964686.
Recent progress in gene therapy has increased the need for non-invasive imaging methods that would allow early diagnosis of successful treatment. Magnetic resonance methods, magnetic resonance imaging (MRI) and spectroscopy (MRS), have shown great promise to achieve this goal. The current mini-review describes recent advances in experimental MRI and MRS to detect individual treatment steps in gene therapy of tumours from gene transfection to therapy response. Limitations of the current techniques are also discussed.
基因治疗的最新进展增加了对非侵入性成像方法的需求，这些方法能够实现对成功治疗的早期诊断。磁共振方法，即磁共振成像（MRI）和光谱学（MRS），已显示出实现这一目标的巨大潜力。本综述介绍了实验性MRI和MRS在检测肿瘤基因治疗中从基因转染到治疗反应的各个治疗步骤方面的最新进展。同时也讨论了当前技术的局限性。
