Wunderlich Michael T, Lins Hartmut, Skalej Martin, Wallesch Claus-W, Goertler Michael
Department of Neurology, Otto-von-Guericke-University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
Clin Neurol Neurosurg. 2006 Sep;108(6):558-63. doi: 10.1016/j.clineuro.2005.12.006. Epub 2006 Feb 2.
Analyses of neuron-specific enolase (NSE) and tau protein in patients with hyperacute ischemic stroke, their association with infarct volume, severity of the neurological deficit, the neurovascular status and functional outcome.
In 66 consecutive patients, serial venous blood samples were taken at 3, 6, 12, 18, 24, 48, 72, 96, and 120 h after stroke onset. The neurovascular status was assessed by repetitive extra- and transcranial duplex sonography. Neurological deficits were quantified by the NIH stroke scale, and functional outcome was assessed with the modified Rankin scale (mRS).
After a first rise within 3 h, NSE decreased followed by a secondary increase until Day 5. Tau protein concentrations showed a continuous increase from admission onward. NSE and tau release were highly correlated with severity of neurological deficits and infarct volume (P = 0.001). NSE, but not tau protein, release was associated to the neurovascular status on admission. NSE and tau protein values were significantly correlated with the functional outcome at 3 months (P < 0.001).
Release kinetics of NSE and tau protein are associated with patients' clinical deficits and infarct volume, and may be used as an additional predictor of the early course and functional outcome.
分析超急性缺血性脑卒中患者的神经元特异性烯醇化酶（NSE）和tau蛋白，及其与梗死体积、神经功能缺损严重程度、神经血管状态和功能转归的关系。
连续纳入66例患者，在卒中发作后3、6、12、18、24、48、72、96和120小时采集系列静脉血样本。通过重复的颅外和经颅双功超声评估神经血管状态。用美国国立卫生研究院卒中量表对神经功能缺损进行量化，并用改良Rankin量表（mRS）评估功能转归。
NSE在3小时内首次升高后下降，随后在第5天出现二次升高。tau蛋白浓度自入院起持续升高。NSE和tau释放与神经功能缺损严重程度和梗死体积高度相关（P = 0.001）。NSE释放与入院时的神经血管状态相关，而tau蛋白则不然。NSE和tau蛋白值与3个月时的功能转归显著相关（P < 0.001）。
NSE和tau蛋白的释放动力学与患者的临床缺损和梗死体积相关，可作为早期病程和功能转归的额外预测指标。
