Fang D, Li Y, Wang X, Yang Z
China Rehabilitation Research Center, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Dec;17(6):439-42.
Neuron-specific enolase (NSE) levels of cerebrospinal fluid (CSF) were measured in 39 patients with ischemic stroke and 15 controls. There was a significant increase of CSF NSE in patients with acute ischemic stroke as compared with the controls. The altered CSF NSE levels were well correlated with the infarct size in CT scan. The CSF NSE levels were higher in 6-patients who were diagnosed as multi-infarct dementia (MID) after 6-month follow-up than in 22 non-MID patients of this series. Our research supports the view that CSF NSE can be a useful biochemical marker for brain ischemia. The importance of CSF NSE for dementia related to ischemic stroke is worth further studying.
对39例缺血性中风患者和15名对照者的脑脊液（CSF）中神经元特异性烯醇化酶（NSE）水平进行了检测。与对照组相比，急性缺血性中风患者的脑脊液NSE显著升高。脑脊液NSE水平的改变与CT扫描中的梗死面积密切相关。在本系列中，6例在6个月随访后被诊断为多发梗死性痴呆（MID）的患者的脑脊液NSE水平高于22例非MID患者。我们的研究支持脑脊液NSE可作为脑缺血有用的生化标志物这一观点。脑脊液NSE对与缺血性中风相关痴呆的重要性值得进一步研究。
