Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.

作者信息

Suzuki Makoto, Shigematsu Hisayuki, Shivapurkar Narayan, Reddy Jyotsna, Miyajima Kuniharu, Takahashi Takao, Gazdar Adi F, Frenkel Eugene P

机构信息

Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical Center, Dallas TX, USA.

出版信息

Cancer Lett. 2006 Oct 28;242(2):222-30. doi: 10.1016/j.canlet.2005.11.002. Epub 2006 Feb 3.

DOI:10.1016/j.canlet.2005.11.002

PMID:16458425

Abstract

We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.

摘要