转化生长因子-β介导的前列腺癌DNA甲基化
TGF-β mediated DNA methylation in prostate cancer.
作者信息
Lee Chung, Zhang Qiang, Zi Xaolin, Dash Atreya, Soares Marcelo B, Rahmatpanah Farahnaz, Jia Zhenyu, McClelland Michael, Mercola Dan
机构信息
The Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Department of Urology, the University of California at Irvine, CA 92868, USA ; The Department of Pathology and Laboratory Medicine, the University of California at Irvine, CA 92697, USA.
The Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
出版信息
Transl Androl Urol. 2012 Jun;1(2):78-88. doi: 10.3978/j.issn.2223-4683.2012.05.06.
Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.
几乎所有肿瘤都存在转化生长因子-β（TGF-β）信号传导的负反馈回路缺陷。包括DNA甲基化在内的基因调控表观遗传机制对正常细胞功能至关重要，在致癌过程中也起主要作用。最近的证据表明，TGF-β信号传导介导癌症的发生和发展。癌症中TGF-β信号传导的许多关键事件包括TGF-β1的自诱导和DNA甲基转移酶（DNMTs）表达增加，这表明DNA甲基化在癌症发生和发展中起重要作用。在本综述中，我们广泛调研了将TGF-β信号传导与前列腺癌中DNA甲基化联系起来的文献。似乎在前列腺癌中检测到的几乎所有DNA甲基化基因都直接或间接与TGF-β信号传导相关。这些知识为我们未来前列腺癌研究方向以及前列腺癌预防和治疗策略提供了依据。
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