Xu Fang-Ping, Xie Dan, Wen Jian-Ming, Wu Hui-Xi, Liu Yong-Dong, Bi Jiong, Lv Zhi-Li, Zeng Yi-Xin, Guan Xin-Yuan
Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Cancer Lett. 2007 Jan 8;245(1-2):69-74. doi: 10.1016/j.canlet.2005.12.030. Epub 2006 Feb 3.
It has been suggested that the steroid receptor coactivatior-3 (SRC-3) gene, also known as AIB1, ACTR, RAC3, p/CIP and TRAM-1, located at 20q12, plays an oncogenic role in several types of human cancers. In this study, we examined the encoded protein expression of SRC-3 and its copy number in 221 human esophageal squamous cell carcinomas (ESCCs). In this ESCC series, the overexpression and increased copy number of SRC-3 gene was detected in 46 and 13% of ESCCs, respectively. In addition, overexpression of SRC-3 was observed more frequently in primary ESCCs in late T stages (T3/T4) than that in earlier T1/T2 stages (P<0.05), but no significant association of expression of SRC-3 and status of lymph node metastases was observed (P>0.05). These results suggest that overexpression of SRC-3, caused by gene amplification/gain or other molecular mechanisms, might provide a selective advantage for the development and local invasion of certain subsets of ESCC. In addition, a significant correlation (P<0.05) of overexpression of SRC-3 with increased cell proliferation (through detection of Ki-67 expression) was observed in these ESCCs. These findings suggest a potential role of SRC-3 in the control of ESCC cell proliferation; such may be responsible, at least in part, for tumorigenesis and/or progression of ESCC.
有人提出，位于20q12的类固醇受体共激活因子-3（SRC-3）基因，也被称为AIB1、ACTR、RAC3、p/CIP和TRAM-1，在几种人类癌症中发挥致癌作用。在本研究中，我们检测了221例人类食管鳞状细胞癌（ESCC）中SRC-3的编码蛋白表达及其拷贝数。在这个ESCC系列中，分别在46%和13%的ESCC中检测到SRC-3基因的过表达和拷贝数增加。此外，在晚期T阶段（T3/T4）的原发性ESCC中，SRC-3的过表达比早期T1/T2阶段更频繁（P<0.05），但未观察到SRC-3表达与淋巴结转移状态之间存在显著关联（P>0.05）。这些结果表明，由基因扩增/获得或其他分子机制引起的SRC-3过表达可能为某些ESCC亚群的发展和局部侵袭提供选择性优势。此外，在这些ESCC中观察到SRC-3过表达与细胞增殖增加（通过检测Ki-67表达）之间存在显著相关性（P<0.05）。这些发现表明SRC-3在控制ESCC细胞增殖中具有潜在作用；这可能至少部分地导致了ESCC的肿瘤发生和/或进展。
