甲基原薯蓣皂苷诱导肝癌细胞HepG2的G2/M期细胞周期阻滞和凋亡。
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
作者信息
Wang Guanghui, Chen Haifeng, Huang Minghui, Wang Naili, Zhang Jinchao, Zhang Yaou, Bai Ganrong, Fong Wang-Fun, Yang Mengsu, Yao Xinsheng
机构信息
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
出版信息
Cancer Lett. 2006 Sep 8;241(1):102-9. doi: 10.1016/j.canlet.2005.10.050. Epub 2006 Feb 2.
Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.
甲基原薯蓣皂苷（NSC-698790）是中药粉背薯蓣（薯蓣科）中的主要生物活性成分之一。在本研究中，我们研究了甲基原薯蓣皂苷对HepG2细胞的抗增殖作用及其诱导细胞毒性的机制。甲基原薯蓣皂苷处理导致HepG2细胞出现G2/M期阻滞和凋亡。这些作用归因于细胞周期蛋白B1的下调以及导致Bax上调和BCL2下调的信号通路，表明甲基原薯蓣皂苷可能是一种新型抗有丝分裂剂。
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