• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effects of Wild Yam Root () Extract on the Gene Expression Profile of Triple-negative Breast Cancer Cells.野山药根提取物对三阴性乳腺癌细胞基因表达谱的影响。
Cancer Genomics Proteomics. 2021 Nov-Dec;18(6):735-755. doi: 10.21873/cgp.20294.
2
Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract.薯蓣（野生山药）根提取物安全性评估修订版最终报告。
Int J Toxicol. 2004;23 Suppl 2:49-54. doi: 10.1080/10915810490499055.
3
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.从野生山药（薯蓣）根提取物中分离出的甾体皂苷薯蓣皂苷在体外对侵袭性人乳腺癌细胞系MDA-MB-231的抗癌潜力。
Arch Biochem Biophys. 2016 Feb 1;591:98-110. doi: 10.1016/j.abb.2015.12.001. Epub 2015 Dec 10.
4
Lipidated steroid saponins from Dioscorea villosa (wild yam).从野山药（Dioscorea villosa）中提取的脂化甾体皂素。
Fitoterapia. 2013 Dec;91:113-124. doi: 10.1016/j.fitote.2013.07.018. Epub 2013 Aug 19.
5
Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells.评估野生山药（薯蓣）根提取物作为乳腺癌细胞潜在表观遗传剂的作用。
In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):59-71. doi: 10.1007/s11626-014-9807-5. Epub 2014 Aug 23.
6
Dioscorea Villosa (Wild Yam) Root Extract.黄药子（野山药）根提取物。
Int J Toxicol. 2023 Dec;42(3_suppl):29S-31S. doi: 10.1177/10915818231204230. Epub 2023 Sep 26.
7
Characterization of steroidal saponins from Dioscorea villosa and D. cayenensis using ultrahigh performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry.利用超高效液相色谱/电喷雾电离四极杆飞行时间质谱法对绒毛薯蓣和卡宴薯蓣中的甾体皂苷进行表征
Planta Med. 2014 Mar;80(4):321-9. doi: 10.1055/s-0033-1360330. Epub 2014 Feb 7.
8
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways.
Food Chem Toxicol. 2008 Sep;46(9):3122-31. doi: 10.1016/j.fct.2008.06.090. Epub 2008 Jul 10.
9
Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts.薯蓣皂素含量是评估薯蓣提取物增强记忆效果的一个新的标准。
J Nat Med. 2021 Jan;75(1):207-216. doi: 10.1007/s11418-020-01451-4. Epub 2020 Sep 26.
10
Effects of Rhizome Extract of Dioscorea batatas and Its Active Compound, Allantoin, on the Regulation of Myoblast Differentiation and Mitochondrial Biogenesis in C2C12 Myotubes.怀山药及其活性成分尿囊素对 C2C12 肌管肌细胞分化和线粒体生物发生的调控作用。
Molecules. 2018 Aug 13;23(8):2023. doi: 10.3390/molecules23082023.

引用本文的文献

1
SORBS1 Knockdown Resists S/G2 Arrest and Apoptosis Caused by Polyphyllin H-Induced DNA Damage in Pancreatic Cancer.SORBS1基因敲低可抵抗重楼皂苷H诱导的胰腺癌DNA损伤所引起的S/G2期阻滞和细胞凋亡。
Oncol Res. 2025 Aug 28;33(9):2491-2506. doi: 10.32604/or.2025.064454. eCollection 2025.
2
Extraction of Active Compounds from and Their Encapsulation Using Mucin and Chitosan for Application in Cosmetic Formulations.从[具体来源未给出]中提取活性化合物并使用粘蛋白和壳聚糖对其进行包封以用于化妆品配方。
Materials (Basel). 2025 May 8;18(10):2178. doi: 10.3390/ma18102178.
3
Clinicopathological and Prognostic Significance of Programmed Death Ligand-1 SP142 Expression in 132 Patients With Triple-negative Breast Cancer.132 例三阴性乳腺癌患者程序性死亡配体-1 SP142 表达的临床病理及预后意义。
In Vivo. 2022 Nov-Dec;36(6):2890-2898. doi: 10.21873/invivo.13030.
4
Use of Saponinosomes from as Anticancer Drug Carriers.来自[具体来源未给出]的皂苷体作为抗癌药物载体的应用。
ACS Omega. 2022 Aug 4;7(32):28421-28433. doi: 10.1021/acsomega.2c03109. eCollection 2022 Aug 16.

本文引用的文献

1
Entelon ( Seed Extract) Prevents Cancer Metastasis via the Downregulation of Interleukin-1 Alpha in Triple-Negative Breast Cancer Cells.依替膦酸二钠（种子提取物）通过下调三阴性乳腺癌细胞中的白细胞介素-1α 来预防癌症转移。
Molecules. 2021 Jun 15;26(12):3644. doi: 10.3390/molecules26123644.
2
Natural and Synthetic Saponins as Vaccine Adjuvants.天然和合成皂苷作为疫苗佐剂
Vaccines (Basel). 2021 Mar 5;9(3):222. doi: 10.3390/vaccines9030222.
3
Is the Membrane Lipid Matrix a Key Target for Action of Pharmacologically Active Plant Saponins?膜脂基质是否是植物药活性皂素作用的关键靶点？
Int J Mol Sci. 2021 Mar 20;22(6):3167. doi: 10.3390/ijms22063167.
4
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy.乳腺癌中肿瘤细胞与免疫微环境之间的相互作用：对免疫治疗的启示
Front Oncol. 2021 Mar 11;11:610303. doi: 10.3389/fonc.2021.610303. eCollection 2021.
5
Immune Therapy Resistance and Immune Escape of Tumors.肿瘤的免疫治疗耐药性与免疫逃逸
Cancers (Basel). 2021 Feb 1;13(3):551. doi: 10.3390/cancers13030551.
6
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice.SARS-CoV-2 刺突糖蛋白疫苗候选物 NVX-CoV2373 在食蟹猴中的免疫原性和在小鼠中的保护作用。
Nat Commun. 2021 Jan 14;12(1):372. doi: 10.1038/s41467-020-20653-8.
7
Exploring the possible use of saponin adjuvants in COVID-19 vaccine.探索皂素佐剂在 COVID-19 疫苗中的可能用途。
Hum Vaccin Immunother. 2020 Dec 1;16(12):2944-2953. doi: 10.1080/21645515.2020.1833579. Epub 2020 Dec 9.
8
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.2021 年的 STRING 数据库：可定制的蛋白质-蛋白质网络，以及用户上传的基因/测量集的功能特征分析。
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612. doi: 10.1093/nar/gkaa1074.
9
NK Cell Adoptive Immunotherapy of Cancer: Evaluating Recognition Strategies and Overcoming Limitations.自然杀伤细胞过继免疫疗法治疗癌症：评估识别策略并克服局限性。
Transplant Cell Ther. 2021 Jan;27(1):21-35. doi: 10.1016/j.bbmt.2020.09.030. Epub 2020 Sep 29.
10
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells.用重定向细胞因子诱导杀伤细胞对三阴性乳腺癌进行过继性细胞治疗。
Oncoimmunology. 2020 Jun 11;9(1):1777046. doi: 10.1080/2162402X.2020.1777046.

野山药根提取物对三阴性乳腺癌细胞基因表达谱的影响。

Effects of Wild Yam Root () Extract on the Gene Expression Profile of Triple-negative Breast Cancer Cells.

机构信息

College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL, U.S.A.

出版信息

Cancer Genomics Proteomics. 2021 Nov-Dec;18(6):735-755. doi: 10.21873/cgp.20294.

DOI:10.21873/cgp.20294
PMID:34697066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8569819/
Abstract

BACKGROUND/AIM: Wild yam extract [Dioscorea villosa, (WYE)] is consistently lethal at low ICs across diverse cancer-lines in vitro. Unlike traditional anti-cancer botanicals, WYE contains detergent saponins which reduce oil-water interfacial tensions causing disintegration of lipid membranes and causing cell lysis, creating an interfering variable. Here, we evaluate WYE at sub-lethal concentrations in MDA-MB-231 triple-negative breast cancer (TNBC) cells.

MATERIALS AND METHODS

Quantification of saponins, membrane potential, lytic death and sub-lethal WYE changes in whole transcriptomic (WT) mRNA, miRNAs and biological parameters were evaluated.

RESULTS

WYE caused 346 differentially expressed genes (DEGs) out of 48,226 transcripts tested; where up-regulated DEGS reflect immune stimulation, TNF signaling, COX2, cytokine release and cholesterol/steroid biosynthesis. Down-regulated DEGs reflect losses in cell division cycle (CDC), cyclins (CCN), cyclin-dependent kinases (CDKs), centromere proteins (CENP), kinesin family members (KIFs) and polo-like kinases (PLKs), which were in alignment with biological studies.

CONCLUSION

Sub-lethal concentrations of WYE appear to evoke pro-inflammatory, steroid biosynthetic and cytostatic effects in TNBC cells.

摘要

背景/目的：野山药提取物[薯蓣属绒毛（WYE）]在体外不同的癌细胞系中以低 ICs 一致致死。与传统的抗癌植物药不同，WYE 含有去污剂皂素，它降低油水界面张力，导致脂质膜破裂和细胞溶解，从而产生干扰变量。在这里，我们在 MDA-MB-231 三阴性乳腺癌（TNBC）细胞中评估亚致死浓度的 WYE。

材料和方法

定量测定皂素、膜电位、裂解性死亡和亚致死 WYE 对全转录组（WT）mRNA、miRNA 和生物学参数的变化。

结果

WYE 引起了 48226 个转录本中 346 个差异表达基因（DEGs）；上调的 DEGs 反映了免疫刺激、TNF 信号、COX2、细胞因子释放和胆固醇/类固醇生物合成。下调的 DEGs 反映了细胞分裂周期（CDC）、细胞周期蛋白（CCN）、细胞周期蛋白依赖性激酶（CDKs）、着丝粒蛋白（CENP）、驱动蛋白家族成员（KIFs）和 Polo 样激酶（PLKs）的损失，这与生物学研究一致。

结论

亚致死浓度的 WYE 似乎在 TNBC 细胞中引起促炎、类固醇生物合成和细胞停滞作用。