Hu Wei-xiao, Zhou Wei, Xia Chun-nian, Wen Xi
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, PR China.
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2213-8. doi: 10.1016/j.bmcl.2006.01.048. Epub 2006 Feb 3.
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.
从水合肼和二硫化碳出发，经三步反应合成了26种硫代氨基脲（III-1至III-26）。这些化合物对P-388、A-549和SGC-7901的体外抗癌活性测试表明，化合物III-15和III-16对P-388和SGC-7901具有较高的抑制能力。进一步测试表明，化合物III-16对SGC-7901的IC50值达到0.032微摩尔。
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