Bartke Andrzej
Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL 62794-9628, USA.
Trends Endocrinol Metab. 2006 Mar;17(2):33-5. doi: 10.1016/j.tem.2006.01.002. Epub 2006 Feb 3.
It was recently reported by Kurosu et al. that overexpression of Klotho, a newly discovered hormone, extends longevity of mice. Because Klotho induces IGF-1 and insulin resistance, these findings appear to contradict previous evidence for increased life span of dwarf mice with reduced IGF-1 and insulin levels and enhanced insulin sensitivity. However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging.
黑须等人最近报道，一种新发现的激素——α-klotho的过表达可延长小鼠寿命。由于α-klotho会诱导胰岛素样生长因子-1（IGF-1）和胰岛素抵抗，这些发现似乎与之前关于IGF-1和胰岛素水平降低以及胰岛素敏感性增强的侏儒小鼠寿命延长的证据相矛盾。然而，在α-klotho小鼠和侏儒小鼠中，IGF-1和胰岛素受体下游信号分子的激活均减少，这表明存在共同的延缓衰老机制。
