Wahl Michael J
Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):661-9. doi: 10.1016/j.ijrobp.2005.10.021.
To critically analyze controversial osteoradionecrosis (ORN) prevention techniques, including preradiation extractions of healthy or restorable teeth and the use of prophylactic antibiotics or hyperbaric oxygen (HBO) treatments for preradiation and postradiation extractions.
The author reviewed ORN studies found on PubMed and in other article references, including studies on overall ORN incidence and pre- and postradiation incidence, with and without prophylactic HBO or antibiotics.
Owing in part to more efficient radiation techniques, the incidence of ORN has been declining in radiation patients over the last 2 decades, but the prevention of ORN remains controversial. A review of the available literature does not support the preradiation extraction of restorable or healthy teeth. There is also insufficient evidence to support the use of prophylactic HBO treatments or prophylactic antibiotics before extractions or other oral surgical procedures in radiation patients.
To prevent ORN, irradiated dental patients should maintain a high level of oral health. A preradiation referral for a dental evaluation and close collaboration by a multidisciplinary team can be invaluable for radiation patients. As with most other dental patients, restorable and healthy teeth should be retained in irradiated patients. The use of prophylactic HBO or antibiotics should be reconsidered for preradiation and postradiation extractions.
批判性分析有争议的放射性骨坏死(ORN)预防技术,包括对健康或可修复牙齿进行放疗前拔牙,以及对放疗前和放疗后拔牙使用预防性抗生素或高压氧(HBO)治疗。
作者回顾了在PubMed及其他文章参考文献中找到的ORN研究,包括关于ORN总体发病率以及放疗前后发病率的研究,有无预防性HBO或抗生素治疗。
部分由于放疗技术更高效,在过去20年中,放疗患者中ORN的发病率一直在下降,但ORN的预防仍存在争议。对现有文献的回顾不支持对可修复或健康牙齿进行放疗前拔牙。也没有足够证据支持在放疗患者拔牙或进行其他口腔外科手术前使用预防性HBO治疗或预防性抗生素。
为预防ORN,接受放疗的牙科患者应保持高水平的口腔健康。放疗前进行牙科评估转诊以及多学科团队的密切合作对放疗患者可能非常宝贵。与大多数其他牙科患者一样,应保留接受放疗患者的可修复和健康牙齿。对于放疗前和放疗后拔牙,应重新考虑使用预防性HBO或抗生素。