Corrada Y, Arias D, Rodríguez R, Tortora M, Gobello C
Small Animal Clinic & Imaging Diagnosis Service, Faculty of Veterinary Medicine, National University of La Plata, La Plata 1900, Argentina.
Theriogenology. 2006 Oct;66(6-7):1557-9. doi: 10.1016/j.theriogenology.2006.01.004. Epub 2006 Feb 3.
Cystic endometrial hyperplasia-pyometra (CEH-P) complex is a progesterone-dependent disease that requires medical treatment in bitches intended for breeding. To test the efficacy and safety of a combined protocol and to assess the effect of age, stage of cycle, previous steroid hormone administration and parity on treatment, 29 bitches diagnosed with CEH-P complex were treated daily with cabergoline 5 microg/kg PO and cloprostenol 1 microg/kg SC for 7-14 days, along with supportive antibiotic and hydration therapies. Before treatment, and on Days 3, 7 and 14, all bitches were evaluated clinically and uterine horn diameter measured during trans-abdominal ultrasonography. Twenty-four of 29 bitches were cured by either Day 7 or 14. Nine bitches had mild digestive side effects. Clinical signs related to pyometra began to improve markedly as early as Day 2 of treatment. Uterine diameters decreased (P < 0.05) by Day 3 of treatment, and continued to gradually decrease, reaching normal size by Day 14. Relapses occurred in 6 of 29 cases. Pregnancy was achieved in one of the two young bitches bred after treatment. No significant relationships were found between success rate and age, stage of the estrous cycle, previous hormone administration or parity. Although no variables affecting treatment results could be identified, this combination of compounds was found to be an efficient and safe for treatment of CEH-P.
囊性子宫内膜增生-子宫积脓（CEH-P）综合征是一种依赖孕酮的疾病，需要对用于繁殖的母犬进行药物治疗。为了测试联合方案的疗效和安全性，并评估年龄、发情周期阶段、先前的类固醇激素给药情况和胎次对治疗的影响，对29只诊断为CEH-P综合征的母犬每天口服卡麦角林5μg/kg和皮下注射氯前列醇1μg/kg，持续7 - 14天，并辅以抗生素和补液治疗。在治疗前以及治疗第3天、第7天和第14天，对所有母犬进行临床评估，并在经腹超声检查时测量子宫角直径。29只母犬中有24只在第7天或第14天治愈。9只母犬有轻微的消化副作用。与子宫积脓相关的临床症状早在治疗第2天就开始明显改善。治疗第3天时子宫直径减小（P < 0.05），并持续逐渐减小，到第14天达到正常大小。29例中有6例复发。治疗后配种的两只年轻母犬中有一只怀孕。在成功率与年龄、发情周期阶段、先前激素给药情况或胎次之间未发现显著关系。虽然未发现影响治疗结果的变量，但发现这种化合物组合对CEH-P的治疗是有效且安全的。
