Belmonte Matthew K, Carper Ruth A
Autism Research Centre, Department of Psychiatry, University of Cambridge, UK.
Brain Cogn. 2006 Jun;61(1):110-21. doi: 10.1016/j.bandc.2005.12.010. Epub 2006 Feb 3.
A pair of monozygotic twins discordant for symptoms of Asperger syndrome was evaluated at the age of 13.45 years using psychometric, morphometric, behavioural, and functional imaging methods. The lower-functioning twin had a smaller brain overall, a smaller right cerebellum, and a disproportionately large left frontal lobe, and manifested almost no differential activation between distractors of high and low-congruence with target visual stimuli. The higher-functioning twin manifested a typically autistic pattern of anterior deactivation and posterior hyperactivation in response to incongruent distractors, overlaid with a typically normal pattern of activation of superior frontal cortex. The morphometric results are consistent with known correlations between brain structure and behaviour in autism, and the physiological results suggest correspondences between structure and function.
一对患阿斯伯格综合征症状不一致的同卵双胞胎在13.45岁时接受了心理测量、形态测量、行为和功能成像方法的评估。功能较低的双胞胎总体脑容量较小，右小脑较小，左额叶不成比例地大，并且在与目标视觉刺激的高一致性和低一致性干扰物之间几乎没有表现出差异激活。功能较高的双胞胎在面对不一致的干扰物时表现出典型的自闭症前失活和后激活模式，叠加有额上回皮质激活的典型正常模式。形态测量结果与自闭症中已知的脑结构与行为之间的相关性一致，生理结果表明结构与功能之间存在对应关系。
