Carr J M, Emery S, Stone B F, Tulin L
Department of Pathology, Beth Israel Hospital, Boston, Massachusetts 02215.
Am J Clin Pathol. 1991 Jun;95(6):774-7. doi: 10.1093/ajcp/95.6.774.
A case of babesiosis complicated by quinine-induced hemolysis is described. A splenectomized woman contracted babesiosis after visiting an endemic area. The patient presented with high fevers and minimal hemolysis. While she was on treatment, the hemolysis increased. The increased hemolysis was initially attributed to babesiosis, but after additional evaluation quinine therapy was found to be the cause. In the setting of this brisk hemolysis, there was an increase in red blood cell inclusions. At first, the inclusions were thought to be Babesia, but iron stain demonstrated that many of the inclusions were hemolysis-induced Pappenheimer bodies. The role of the clinical laboratory in sorting out this confusing picture is presented.
本文描述了一例巴贝斯虫病合并奎宁诱导的溶血病例。一名脾切除术后的女性在前往疫区后感染了巴贝斯虫病。患者出现高热和轻微溶血。在治疗过程中，溶血加重。起初，溶血加重被归因于巴贝斯虫病，但经过进一步评估，发现是奎宁治疗所致。在这种快速溶血的情况下，红细胞内含物增加。起初，这些内含物被认为是巴贝斯虫，但铁染色显示许多内含物是溶血诱导的帕彭海默小体。本文介绍了临床实验室在理清这一复杂情况中所起的作用。
