Pal Dilipkumar, Nandi Mrinmay
Division of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj-757 086, Orissa, India.
Acta Pol Pharm. 2005 Sep-Oct;62(5):355-61.
The dried extracts of aerial parts of Celesia coromandeliane Vahl. (Scrophulariaceae) were evaluated for CNS activities in mice. The methanol extract of aerial part of Celesia coromandeliane (MECC) was found to cause significant depression in general as well as exploratory behavioral profiles in mice. MECC showed reduction in muscle relaxant activity by 30 degrees inclined screen test, as well as potential remarkably the pentobarbitone sodium-, diazepam- and meprobamate-induced sleeping time of mice. The petroleum ether extract of aerial parts of Celesia coromandeliane (PECC) showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. Pretreatment with PECC caused significant protection against strychnine- and leptazol-induced convulsions. All these results were compared with respective controls for the evaluation of significance. The presence of steroids in PECC and saponins in MECC might be responsible for respective CNS activities in mice.
对印度石龙尾（玄参科）地上部分的干燥提取物进行了小鼠中枢神经系统活性评估。发现印度石龙尾地上部分的甲醇提取物（MECC）在整体以及小鼠探索行为方面均引起显著抑制。通过30度倾斜筛板试验，MECC显示肌肉松弛活性降低，并且显著延长了小鼠由戊巴比妥钠、地西泮和甲丙氨酯诱导的睡眠时间。印度石龙尾地上部分的石油醚提取物（PECC）表现出显著的镇痛特性，1.2%乙酸溶液诱导的小鼠扭体和伸展次数显著减少证明了这一点。用PECC预处理可显著预防士的宁和戊四氮诱导的惊厥。为评估显著性，将所有这些结果与各自的对照组进行了比较。PECC中甾体的存在以及MECC中皂苷的存在可能分别是导致小鼠中枢神经系统活性的原因。
