Wood P M
Department of Biochemistry, University of Bristol, U.K.
Biochim Biophys Acta. 1991 May 23;1058(1):5-7. doi: 10.1016/s0005-2728(05)80256-7.
An earlier paper (Wood, P.M. (1983) FEBS Lett. 164, 223-226) proposed that the covalent links that characterize c-type haem originated in order to prevent the haem being lost into the external medium. This is discussed in relation to Gram-negative and Gram-positive bacteria, cyanobacterial thylakoids and eukaryotes. The practical application is for unravelling complex electron transfer chains: c-type cytochromes may be assumed to be absent from the cytoplasm. Sulphate reducing bacteria provide the only confirmed exception to this rule. Examples of non-covalent haem at risk of being lost are considered. Analogies are drawn with flavin and pyrroloquinoline quinone as prosthetic groups.
一篇较早的论文（伍德，P.M.（1983年）《欧洲生物化学学会联合会快报》164卷，223 - 226页）提出，构成c型血红素特征的共价键的形成是为了防止血红素流失到外部介质中。本文针对革兰氏阴性菌和革兰氏阳性菌、蓝藻类囊体以及真核生物对此进行了讨论。其实际应用在于解析复杂的电子传递链：可以假定细胞质中不存在c型细胞色素。硫酸盐还原菌是该规则唯一已证实的例外情况。文中考虑了有流失风险的非共价血红素的例子。文中还将其与作为辅基的黄素和吡咯喹啉醌进行了类比。
