Loffing Johannes, Flores Sandra Y, Staub Olivier
Department of Medicine: Unit of Anatomy, University of Fribourg, CH-1700 Fribourg, Switzerland.
Annu Rev Physiol. 2006;68:461-90. doi: 10.1146/annurev.physiol.68.040104.131654.
The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport. This kinase is very rapidly regulated at the transcriptional level as well as via posttranslational modifications involving phosphorylation by the MAP or PI-3 kinase pathways and/or ubiquitylation. Although Sgk1 is a cell survival kinase, its primary role likely concerns the regulation of epithelial ion transport, as suggested by the phenotype of Sgk1-null mice, which display a defect in Na( homeostasis owing to disturbed renal tubular Na+ handling. In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport.
血清/糖皮质激素诱导激酶Sgk1在上皮离子转运调节中发挥重要作用。该激酶在转录水平以及通过涉及丝裂原活化蛋白激酶（MAP）或磷脂酰肌醇-3激酶（PI-3激酶）途径磷酸化和/或泛素化的翻译后修饰进行非常快速的调节。尽管Sgk1是一种细胞存活激酶，但正如Sgk1基因敲除小鼠的表型所表明的那样，其主要作用可能与上皮离子转运的调节有关，这些小鼠由于肾小管钠处理紊乱而表现出钠稳态缺陷。在本综述中，我们首先讨论Sgk1及其旁系同源物的分子、细胞和调节方面。然后我们讨论其在上皮离子转运转生理学和病理生理学中的作用。
