条纹蛋白家族：树突棘中的一个新信号平台。

The striatin family: a new signaling platform in dendritic spines.

作者信息

Benoist Marion, Gaillard Stéphane, Castets Francis

机构信息

INSERM-UMR 641, Institut Jean Roche, Université de la Méditerranée, Faculté de Médecine Secteur-Nord, Boulevard P. Dramard, 13916 Marseille cedex 20, France.

出版信息

J Physiol Paris. 2006 Mar-May;99(2-3):146-53. doi: 10.1016/j.jphysparis.2005.12.006. Epub 2006 Feb 7.

DOI:10.1016/j.jphysparis.2005.12.006

PMID:16460920

Abstract

Proteins of the striatin family have been identified in all multicellular animals. They are multidomain molecules containing several protein-interacting motifs. In mammals, these proteins are principally expressed in neurons with a somato-dendritic localization and high concentration in dendritic spines. Recent reports suggest that the proteins of the striatin family are molecular scaffolds that act as links between signal transduction and vesicular trafficking.

摘要

在所有多细胞动物中都已鉴定出striatin家族的蛋白质。它们是包含多个蛋白质相互作用基序的多结构域分子。在哺乳动物中，这些蛋白质主要在神经元中表达，定位于胞体-树突，且在树突棘中浓度较高。最近的报告表明，striatin家族的蛋白质是分子支架，在信号转导和囊泡运输之间起连接作用。