Matoba Y, Matsumori A, Okada I, Ohkusa T, Kawai C
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Jpn Circ J. 1991 Apr;55(4):407-16. doi: 10.1253/jcj.55.407.
The effect of cyclosporine on the immunopathogenesis of viral myocarditis was studied using a murine viral myocarditis model. Mice in the treated group had a higher mortality rate compared with those of the infected control group before day 15 (47/67 vs. 14/31, p less than 0.05). On day 7, treated mice showed higher titers of anti-heart autoantibody than the control group (12 +/- 7 vs 4 +/- 2, p less than 0.05), but no significant difference was seen on day 14 (28 +/- 15 vs. 39 +/- 34). Histologic lesions, lymphocyte subsets in the peripheral blood and heart in situ, the neutralizing antibody, and virus concentrations in the heart showed no significant differences between these groups. This study suggests that with the use of cyclosporine the production of anti-heart autoantibody was enhanced in the early stages of viral myocarditis in mice, and was associated with higher mortality rate.
利用小鼠病毒性心肌炎模型研究了环孢素对病毒性心肌炎免疫发病机制的影响。在第15天之前，治疗组小鼠的死亡率高于感染对照组（47/67对14/31，p<0.05）。在第7天，治疗组小鼠的抗心脏自身抗体滴度高于对照组（12±7对4±2，p<0.05），但在第14天未观察到显著差异（28±15对39±34）。这些组之间在组织学病变、外周血和心脏原位的淋巴细胞亚群、中和抗体以及心脏中的病毒浓度方面均未显示出显著差异。本研究表明，使用环孢素后，小鼠病毒性心肌炎早期抗心脏自身抗体的产生增加，且与较高的死亡率相关。
