Maixnerová D, Honsová E, Merta M, Reiterová J, Rysavá R, Tesar V, Obeidová H, Motan J
Department of Nephrology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Prague Med Rep. 2005;106(3):283-90.
Our study is aimed to reveal the frequency and clinical significance of the coincidence of two widely spread entities, e.g. minimal change disease (MCD) and IgA nephropathy (IgAN), claimed to be found in an overwhelming number in some Asian regions. We retrospectively analyzed clinical and histological data from 627 renal biopsies, performed in our department from January 2002 to January 2005 and completed electron microscopy in 112 specimens diagnosed as IgAN. The coincidence of IgAN and MCD was found in 8 patients (7.1%). The coincidence of IgAN and minimal change nephrotic syndrome (MCNS) clinically--especially presence of nephrotic syndrome and the response to drug therapy (with corticosteroids)--behaves as "pure" MCN. Our data from Czech Republic seem to suggest that the combination of IgAN with MCNS can be found relatively frequently not only in Asian patients (as stressed by some authors of Asian origin) but also in European inhabitants. The pathogenesis of the coincidence of IgAN and MCD needs to be elucidated by further studies.
我们的研究旨在揭示两种广泛存在的疾病——微小病变病（MCD）和IgA肾病（IgAN）——并存的频率及其临床意义，据称在一些亚洲地区这种情况大量存在。我们回顾性分析了2002年1月至2005年1月在我们科室进行的627例肾活检的临床和组织学数据，并对112例诊断为IgAN的标本进行了电子显微镜检查。发现8例患者（7.1%）存在IgAN和MCD并存的情况。IgAN与微小病变肾病综合征（MCNS）并存时，在临床上——尤其是肾病综合征的存在以及对药物治疗（使用皮质类固醇）的反应——表现为“单纯”的MCN。我们来自捷克共和国的数据似乎表明，IgAN与MCNS并存的情况不仅在亚洲患者中（如一些亚洲作者所强调的）相对常见，在欧洲居民中也较为常见。IgAN和MCD并存的发病机制需要进一步研究来阐明。
