Smit Joost J, Lukacs Nicholas W
Department of Pathology, UM Medical School, 5214 Medical Science I, 1301 Catherine Road, Ann Arbor, MI 48109-0602, United States of America.
Eur J Pharmacol. 2006 Mar 8;533(1-3):277-88. doi: 10.1016/j.ejphar.2005.12.064. Epub 2006 Feb 7.
Inflammatory cell recruitment is a hallmark phenomenon of all inflammatory diseases, including allergic asthma. In allergy and asthma, recruitment of inflammatory cells such as T cells, dendritic cells, mast cells, eosinophils and neutrophils, is mediated via a number of chemokines and their receptors. Not only are chemokines involved in recruitment of these cells, they also play a role in activation and differentiation of inflammatory cells, among others, by selectively activating Th1 or Th2 cells or by effects on epithelial or endothelial cells. Binding of chemokines with their receptors has been demonstrated to be highly promiscuous and the subsequent activation pattern on effector cells is very heterogeneous, which has lead to confusion and has complicated research in this field. Nonetheless, chemokines and their receptors are important potential therapeutical targets in allergy and asthma because of their central role in cell recruitment and activation during inflammation.
炎症细胞募集是包括过敏性哮喘在内的所有炎症性疾病的标志性现象。在过敏和哮喘中，T细胞、树突状细胞、肥大细胞、嗜酸性粒细胞和中性粒细胞等炎症细胞的募集是通过多种趋化因子及其受体介导的。趋化因子不仅参与这些细胞的募集，它们还通过选择性激活Th1或Th2细胞或通过对上皮细胞或内皮细胞的作用，在炎症细胞的激活和分化等过程中发挥作用。趋化因子与其受体的结合已被证明具有高度的混杂性，并且效应细胞上随后的激活模式非常异质性，这导致了该领域研究的混乱和复杂化。尽管如此，趋化因子及其受体仍是过敏和哮喘中重要的潜在治疗靶点，因为它们在炎症期间细胞募集和激活中起着核心作用。
