Mogulkoc Rasim, Baltaci Abdulkerim Kasim, Oztekin Esma, Aydin Leyla, Sivrikaya Abdullah
Department of Physiology, Meram Medical School, Selcuk University, 42080 Konya, Turkey.
Life Sci. 2006 Jun 13;79(3):311-5. doi: 10.1016/j.lfs.2006.01.009. Epub 2006 Feb 7.
Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism+melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues. MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism+melatonin supplemented groups (p<0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p<0.001). These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage.
甲状腺功能受损会导致身体不同器官发生病理变化。体内和体外研究结果表明，甲状腺激素对氧化应激有相当大的影响。褪黑素通过其清除自由基和直接抗氧化作用来减少氧化损伤。本研究旨在确定为期3周的腹腔注射褪黑素对大鼠实验性甲状腺功能亢进所致氧化损伤的影响。实验动物分为3组（对照组、甲状腺功能亢进组、甲状腺功能亢进+褪黑素组）。测定不同组织中的丙二醛（MDA）和谷胱甘肽（GSH）水平。甲状腺功能亢进组脑、肝和心脏组织中的MDA水平显著高于对照组和补充褪黑素的甲状腺功能亢进组（p<0.001）。在除甲状腺功能亢进外还给予褪黑素的组中观察到最高的GSH水平（p<0.001）。这些结果表明，甲状腺功能亢进会增加大鼠脑、肝和心脏组织中的氧化损伤。补充褪黑素也可能抑制氧化损伤。
