AID参与体细胞高频突变和类别转换重组。

AID in somatic hypermutation and class switch recombination.

作者信息

Longerich Simonne, Basu Uttiya, Alt Frederick, Storb Ursula

机构信息

Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E. 58(th) Street, Chicago, IL 60615, USA.

出版信息

Curr Opin Immunol. 2006 Apr;18(2):164-74. doi: 10.1016/j.coi.2006.01.008. Epub 2006 Feb 7.

DOI:10.1016/j.coi.2006.01.008

PMID:16464563

Abstract

Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

摘要

体细胞高频突变和类别转换重组是由激活诱导脱氨酶（AID）对DNA中的脱氧胞嘧啶进行脱氨作用引发的。最近，人们对AID如何靶向Ig基因亚区域中的双链DNA、该过程中辅助因子的参与情况和翻译后修饰、DNA“修复”机制的借用以及AID的进化进行了大量研究。