取代香豆素作为有效的5-脂氧合酶抑制剂。
Substituted coumarins as potent 5-lipoxygenase inhibitors.
作者信息
Grimm Erich L, Brideau Christine, Chauret Nathalie, Chan Chi-Chung, Delorme Daniel, Ducharme Yves, Ethier Diane, Falgueyret Jean-Pierre, Friesen Richard W, Guay Jocelyne, Hamel Pierre, Riendeau Denis, Soucy-Breau Chantal, Tagari Philip, Girard Yves
机构信息
Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Hwy, Kirkland, Que., Canada H9H 3L1.
出版信息
Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. doi: 10.1016/j.bmcl.2006.01.085. Epub 2006 Feb 7.
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
白三烯生物合成抑制剂有潜力成为治疗哮喘和炎症性疾病的药物。已合成了一系列新型取代香豆素衍生物，并就它们通过人5-脂氧合酶抑制白三烯形成的能力评估了构效关系。
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