Tsvettsikh V E, Krylov V I, Lerner G N, Berdichevskiĭ B A
Ter Arkh. 1991;63(2):105-7.
The authors analyze the status of cationic transmembranous transport in leukocytes in patients with chronic secondary pyelonephritis (CPN) as related to the clinical manifestations of pathology and immune response. 117 patients with CPN were examined. In 58 patients, pyelonephritis was associated with nephrolithiasis, in 59 with different abnormalities of the kidneys and urinary tract. The immunity status was examined according to the content of IgA, IgG, IgM, T and B lymphocytes, complement (CH50), the phagocytic neutrophil test and secretory IgA in the urine. In white blood cells, a study was made of the activity of Mg(2+)-, Na(+)-K(+)-, Ca(2+)-ATPases. As a result of the studies the patients were found to have low functional activity of Ca(2+)-ATPase, Na(+)-K(+)-ATPase during the clinical manifestations of pyelonephritis. Analysis of the frequency of enzymatic activity values showed their nonuniformity. In some patients, it was lowered (less than X--1), whereas in others, it appeared increased (over X+1). Patients with an enzymatic activity below X--1 manifested a decrease of the content of IgA, IgG, IgM, T and B lymphocytes, and of phagocytic activity of neutrophils as compared to patients exhibiting a high enzymatic activity. The conclusion is made about the relationship between enzymatic function and immune response. It is recommended that drugs possessing membrane-protective and reparative pharmacological effects be included into multimodality therapy.
作者分析了慢性继发性肾盂肾炎（CPN）患者白细胞中阳离子跨膜转运的状况，及其与病理临床表现和免疫反应的关系。对117例CPN患者进行了检查。其中58例患者的肾盂肾炎与肾结石有关，59例与肾脏和尿路的不同异常有关。根据IgA、IgG、IgM、T和B淋巴细胞的含量、补体（CH50）、中性粒细胞吞噬试验以及尿中分泌型IgA来检查免疫状态。对白细胞中的Mg(2+)-、Na(+)-K(+)-、Ca(2+)-ATP酶活性进行了研究。研究结果发现，在肾盂肾炎临床表现期间，患者的Ca(2+)-ATP酶、Na(+)-K(+)-ATP酶功能活性较低。对酶活性值频率的分析表明其不均匀性。在一些患者中，酶活性降低（低于X-1），而在另一些患者中，酶活性升高（高于X+1）。与酶活性高的患者相比，酶活性低于X-1的患者IgA、IgG、IgM、T和B淋巴细胞含量以及中性粒细胞吞噬活性降低。得出了酶功能与免疫反应之间存在关联的结论。建议在多模式治疗中纳入具有膜保护和修复药理作用的药物。
