Mammen M, Buga G A B, Iputo J E
Department of Medical Biology, Walter Sisulu University, Mthatha, Eastern Cape, South Africa.
S Afr Med J. 2005 Dec;95(12):955-8.
To determine the relationship between pre-eclampsia and glucose intolerance among rural women from the Transkei region of South Africa.
Women with confirmed pre-eclampsia underwent a 75 g, 3-hour oral glucose tolerance test. A control group of normotensive pregnant women were subjected to a similar glucose tolerance test. Pre-eclampsia was defined as blood pressure (BP) of at least 140/90 mmHg occurring for the first time after mid-pregnancy, in association with proteinuria. The control group comprised women with singleton pregnancy and normal BP, with age, parity and gestational age comparable to those of the pre-eclampsia group.
There were 117 subjects in the pre-eclampsia group and 94 in the normotensive pregnancy group. Mean fasting plasma glucose levels in the pre-eclampsia group (3.88 +/- 0.05 mmol/l) were similar to levels in the normotensive group (3.97 +/- 0.05 mmol/l, p = 0.214). Peak post-load plasma glucose levels in the pre-eclampsia group (5.96 +/- 0.12 mmol/l) were similar to levels in the normotensive group (5.71 +/- 0.13 mmol/l, p = 0.180), and post-load incremental glucose area under the curve in the preeclampsia group (4.16 +/- 0.21) was similar to that in the normotensive group (3.95 +/- .21, p = 0.495).
Rural women with pre-eclampsia from the Transkei region of South Africa have normal glucose tolerance.
确定南非特兰斯凯地区农村妇女先兆子痫与糖耐量异常之间的关系。
确诊为先兆子痫的妇女接受了75克、3小时口服葡萄糖耐量试验。一组血压正常的孕妇对照组也进行了类似的葡萄糖耐量试验。先兆子痫的定义为妊娠中期后首次出现血压（BP）至少为140/90 mmHg，并伴有蛋白尿。对照组包括单胎妊娠且血压正常的妇女，其年龄、产次和孕周与先兆子痫组相当。
先兆子痫组有117名受试者，血压正常妊娠组有94名。先兆子痫组的平均空腹血糖水平（3.88±0.05 mmol/l）与血压正常组（3.97±0.05 mmol/l，p = 0.214）相似。先兆子痫组的负荷后血糖峰值水平（5.96±0.12 mmol/l）与血压正常组（5.71±0.13 mmol/l，p = 0.180）相似，且先兆子痫组的负荷后血糖曲线下增量面积（4.16±0.21）与血压正常组（3.95±0.21，p = 0.495）相似。
来自南非特兰斯凯地区患先兆子痫的农村妇女糖耐量正常。
