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The Ah receptor and the mechanism of dioxin toxicity.

作者信息

Landers J P, Bunce N J

机构信息

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905.

出版信息

Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):273-87. doi: 10.1042/bj2760273.

DOI:10.1042/bj2760273
PMID:1646595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1151088/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b5c/1151088/65dfefb3d1bd/biochemj00158-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b5c/1151088/8aa67037e928/biochemj00158-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b5c/1151088/65dfefb3d1bd/biochemj00158-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b5c/1151088/8aa67037e928/biochemj00158-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b5c/1151088/65dfefb3d1bd/biochemj00158-0018-a.jpg

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1
The Ah receptor and the mechanism of dioxin toxicity.芳烃受体与二噁英毒性机制
Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):273-87. doi: 10.1042/bj2760273.
2
The role of receptors in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity.受体在2,3,7,8-四氯二苯并对二恶英（TCDD）毒性中的作用。
Arch Toxicol Suppl. 1985;8:43-60. doi: 10.1007/978-3-642-69928-3_5.
3
2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.2,3,7,8-四氯二苯并对二恶英：毒性与芳烃（Ah）位点的分离
Mol Pharmacol. 1980 Jan;17(1):86-94.
4
Location of Ah receptor for dioxin.二噁英的芳烃受体位置。
J Am Acad Dermatol. 1984 Oct;11(4 Pt 1):663-4. doi: 10.1016/s0190-9622(84)80401-6.
5
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.缺乏二噁英结合型芳烃受体的小鼠的免疫系统损伤与肝纤维化
Hum Exp Toxicol. 1996 Feb;15(2):176-9. doi: 10.1177/096032719601500208.
6
Comparative genetic mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced tumors.
Prog Clin Biol Res. 1990;331:177-86.
7
The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.二噁英-Ah受体复合物的DNA识别位点。核苷酸序列及功能分析。
J Biol Chem. 1988 Nov 25;263(33):17221-4.
8
Ah receptor: relevance of mechanistic studies to human risk assessment.芳烃受体：机制研究与人类风险评估的相关性。
Environ Health Perspect. 1987 Dec;76:71-7. doi: 10.1289/ehp.877671.
9
2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity mechanisms.2,3,7,8-四氯二苯并对二恶英的毒性机制
Toxicol Lett. 1988 Jul;42(1):1-3. doi: 10.1016/0378-4274(88)90096-3.
10
Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans.多氯二苯并对二恶英和二苯并呋喃的比较毒理学及作用机制
Annu Rev Pharmacol Toxicol. 1986;26:371-99. doi: 10.1146/annurev.pa.26.040186.002103.

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本文引用的文献

1
Formation of 2,3,7,8-tetrachlorodibenzodioxin by thermal decomposition of sodium 2,4,5,-trichlorophenate.通过2,4,5-三氯苯甲酸钠的热分解形成2,3,7,8-四氯二苯并二恶英。
Nature. 1971 Aug 6;232(5310):395-6. doi: 10.1038/232395a0.
2
Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.2,3,7,8-四氯二苯并对二噁英（TCDD）在金黄叙利亚仓鼠体内的组织分布、排泄及代谢
Toxicol Appl Pharmacol. 1980 Oct;56(1):78-85. doi: 10.1016/0041-008x(80)90132-5.
3
Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic compounds.
膳食 AhR 配体调节肠道免疫细胞和肠道微生物群落中 AhRR 的表达。
Int J Mol Sci. 2020 Apr 30;21(9):3189. doi: 10.3390/ijms21093189.
4
Copy Number Changes Identified Using Whole Exome Sequencing in Nonsyndromic Cleft Lip and Palate in a Honduran Population.使用全外显子组测序在洪都拉斯人群中非综合征性唇腭裂中鉴定拷贝数变化。
Birth Defects Res. 2017 Oct 2;109(16):1257-1267. doi: 10.1002/bdr2.1063. Epub 2017 Jul 27.
5
Modeling adsorption of brominated, chlorinated and mixed bromo/chloro-dibenzo--dioxins on C fullerene using Nano-QSPR.使用纳米定量构效关系（Nano-QSPR）模拟溴代、氯代及混合溴/氯二苯并二恶英在C富勒烯上的吸附
Beilstein J Nanotechnol. 2017 Mar 31;8:752-761. doi: 10.3762/bjnano.8.78. eCollection 2017.
6
Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells.人、小鼠和大鼠原代B细胞中TCDD诱导的芳烃受体（AhR）介导的基因表达的比较分析。
Toxicol Appl Pharmacol. 2017 Feb 1;316:95-106. doi: 10.1016/j.taap.2016.11.009. Epub 2016 Nov 30.
7
Association between Dioxin and Diabetes Mellitus in an Endemic Area of Exposure in Taiwan: A Population-Based Study.台湾某二噁英暴露流行地区二噁英与糖尿病之间的关联：一项基于人群的研究。
Medicine (Baltimore). 2015 Oct;94(42):e1730. doi: 10.1097/MD.0000000000001730.
8
Implications of NQO1 in cancer therapy.NQO1在癌症治疗中的意义。
BMB Rep. 2015 Nov;48(11):609-17. doi: 10.5483/bmbrep.2015.48.11.190.
9
Combined 17β-Estradiol with TCDD Promotes M2 Polarization of Macrophages in the Endometriotic Milieu with Aid of the Interaction between Endometrial Stromal Cells and Macrophages.17β-雌二醇与2,3,7,8-四氯二苯并对二恶英联合借助子宫内膜基质细胞与巨噬细胞之间的相互作用促进子宫内膜异位环境中巨噬细胞的M2极化。
PLoS One. 2015 May 7;10(5):e0125559. doi: 10.1371/journal.pone.0125559. eCollection 2015.
10
Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia.葡萄糖可诱导肠道人尿苷二磷酸葡萄糖醛酸基转移酶（UGT）1A1，以预防新生儿高胆红素血症。
Sci Rep. 2014 Sep 11;4:6343. doi: 10.1038/srep06343.
多环芳烃处理的小鼠中鸟氨酸脱羧酶诱导与Ah位点之间的关联。
J Biol Chem. 1980 Jul 25;255(14):6836-42.
4
Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on nuclear RNA polymerase activity in the rat liver and thymus.
Biochem Pharmacol. 1982 Aug 1;31(15):2459-62. doi: 10.1016/0006-2952(82)90054-5.
5
Influence of 2,3,7,8-TCDD on the protein composition of the plasma membrane of hepatic cells from the rat.
Biochem Biophys Res Commun. 1982 Jul 16;107(1):68-74. doi: 10.1016/0006-291x(82)91670-9.
6
Selective binding of chicken progesterone receptor A subunit to a DNA fragment containing ovalbumin gene sequences.
Biochem Biophys Res Commun. 1982 Mar 15;105(1):96-104. doi: 10.1016/s0006-291x(82)80015-6.
7
Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens.来自雌激素撤离的未成熟雏鸡以及老龄不产蛋母鸡的已发育输卵管中无功能的孕酮受体。
Endocrinology. 1982 Jul;111(1):30-6. doi: 10.1210/endo-111-1-30.
8
Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.Ah位点的调节基因产物。小鼠肝癌克隆中受体突变体的特征分析。
J Biol Chem. 1982 Jun 10;257(11):6402-7.
9
PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells.
Toxicol Lett. 1982 Sep;13(1-2):87-93. doi: 10.1016/0378-4274(82)90142-4.
10
Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. I. Teratogenicity of 3, 3', 4, 4', 5, 5',-hexachlorobiphenyl.对称多氯联苯异构体对小鼠胚胎和胎儿发育的影响。I. 3, 3', 4, 4', 5, 5'-六氯联苯的致畸性。
Toxicol Appl Pharmacol. 1981 Nov;61(2):269-76. doi: 10.1016/0041-008x(81)90417-8.