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通过求解二次方程组进行漫射光学层析成像:理论与模拟

Diffuse optical tomography through solving a system of quadratic equations: theory and simulations.

作者信息

Kanmani B, Vasu R M

机构信息

Department of Instrumentation, Indian Institute of Science, Bangalore, India.

出版信息

Phys Med Biol. 2006 Feb 21;51(4):981-98. doi: 10.1088/0031-9155/51/4/015. Epub 2006 Feb 1.

Abstract

This paper discusses the iterative solution of the nonlinear problem of optical tomography. In the established forward model-based iterative image reconstruction (MOBIIR) method a linear perturbation equation containing the first derivative of the forward operator is solved to obtain the update vector for the optical properties. In MOBIIR, the perturbation equation is updated by recomputing the first derivative after each update of the optical properties. In the method presented here a nonlinear perturbation equation, containing terms up to the second derivative, is used to iteratively solve for the optical property updates. Through this modification, reconstructions with reasonable contrast recovery and accuracy are obtained without the need for updating the perturbation equation and therefore eliminating the outer iteration of the usual MOBIIR algorithm. To improve the performance of the algorithm the outer iteration is reintroduced in which the perturbation equation is recomputed without re-estimating the derivatives and with only updated computed data. The system of quadratic equations is solved using either a modified conjugate gradient descent scheme or a two-step linearized predictor-corrector scheme. A quick method employing the adjoint of the forward operator is used to estimate the derivatives. By solving the nonlinear perturbation equation it is shown that the iterative scheme is able to recover large contrast variations in absorption coefficient with improved noise tolerance in data. This ability has not been possible so far with linear algorithms. This is demonstrated by presenting results of numerical simulations from objects with inhomogeneous inclusions in absorption coefficient with different contrasts and shapes.

摘要

本文讨论了光学层析成像非线性问题的迭代解。在基于正向模型的迭代图像重建(MOBIIR)方法中,求解一个包含正向算子一阶导数的线性扰动方程,以获得光学特性的更新向量。在MOBIIR中,每次更新光学特性后,通过重新计算一阶导数来更新扰动方程。在此处提出的方法中,使用一个包含二阶导数项的非线性扰动方程来迭代求解光学特性更新。通过这种修改,无需更新扰动方程即可获得具有合理对比度恢复和精度的重建结果,从而消除了常规MOBIIR算法的外层迭代。为了提高算法性能,重新引入外层迭代,其中在不重新估计导数且仅使用更新后的计算数据的情况下重新计算扰动方程。使用改进的共轭梯度下降方案或两步线性化预测校正方案求解二次方程组。采用正向算子伴随的快速方法用于估计导数。通过求解非线性扰动方程表明,该迭代方案能够恢复吸收系数中的大对比度变化,并提高数据中的噪声容限。到目前为止,线性算法还无法实现这种能力。通过给出具有不同对比度和形状的吸收系数不均匀包含物的物体的数值模拟结果来证明这一点。

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