Zheng Xiaohan, Voigt Herbert F
Biomedical Engineering Department and Hearing Research Center, Boston University, 44 Cummington Street, Boston, MA, 02215, USA.
Ann Biomed Eng. 2006 Apr;34(4):697-708. doi: 10.1007/s10439-005-9073-5. Epub 2006 Feb 9.
A computational model of the neural circuitry of the gerbil dorsal cochlear nucleus (DCN), based on the MacGregor's neuromime model, was used to simulate type III unit (P-cell) responses to notch noise stimuli. The DCN patch model is based on a previous computational model of the cat DCN [Hancock, K. E., and H. F. Voigt. Ann. Biomed. Eng. 27:73-87, 1999]. According to the experimental study of Parsons et al. [Ann. Biomed. Eng. 29:887-896, 2001], the responses of gerbil DCN type III units to notch noise stimuli are similar to those of cat DCN type IV units, which are thought to be spectral notch detectors. This suggests that type III units in the gerbil DCN may serve as spectral notch detectors. In this modeling study, a simplified notch noise response plot-spike discharge rate vs. notch cutoff frequency plot-was used to compare model responses to the experimental results. Parameter estimation and sensitivity analysis of three connection parameters within the DCN patch have been studied and shows the model is robust, providing reasonable fits to the experimental data from 14 of 15 type III units examined [work supported by a grant from NIDCD, Boston University's Biomedical Engineering department and Hearing Research Center].
基于麦格雷戈神经模拟模型，建立了沙鼠背侧耳蜗核（DCN）神经回路的计算模型，用于模拟III型单元（P细胞）对带凹口噪声刺激的反应。DCN斑块模型基于先前猫DCN的计算模型[汉考克，K.E.，和H.F.沃伊特。《生物医学工程年鉴》27:73 - 87，1999]。根据帕森斯等人的实验研究[《生物医学工程年鉴》29:887 - 896，2001]，沙鼠DCN III型单元对带凹口噪声刺激的反应与猫DCN IV型单元相似，后者被认为是频谱带凹口探测器。这表明沙鼠DCN中的III型单元可能充当频谱带凹口探测器。在这项建模研究中，使用了一种简化的带凹口噪声响应图——放电率与带凹口截止频率图——来比较模型反应与实验结果。对DCN斑块内三个连接参数进行了参数估计和敏感性分析，结果表明该模型具有鲁棒性，对所研究的15个III型单元中的14个单元的实验数据提供了合理的拟合[由美国国立聋病和其他交流障碍研究所、波士顿大学的生物医学工程系和听力研究中心的一项资助支持]。
