Ritland S
Scand J Gastroenterol. 1975;10(1):5-15.
Quantitative determination of the abnormal plasma lipoprotein of cholestasis LP-X has been performed in 81 LP-X positive patients with different liver disorders. Great variations in the plasma concentration of LP-X were demonstrated both in the 45 patients with intrahepatic cholestasis (acute hepatitis, toxic hepatitis, primary biliary cirrhosis and cholangitis) and in the 36 patients with extrahepatic cholestasis (extrahepatic biliary obstruction by tumours and choledocholithiasis). The plasma concentratkons of LP-X in the patients with extrahepatic cholestasis (median 158 mg/100 ml) were significantly (psmaller than 0.001) higher than in the patients with intraphepatic cholestasis (median 25 mg/100 ml) was exceeded by 42% of the patients with extrahepatic biliary obstruction, and 33% of the patients with extrahepatic biliary obstruction, had LP-X LEVELS ABOVE 400 MG/100ML. The plasma concentration of LP-X was significantly correlated to the plasma activity of alkaline phosphatases and serum bilirubin, but seemed to be superior to these two parameters in the differentiation between intrahepatic and extrahepatic cholestasis. Plasma levels of LP-X above 400 mg/100 ml are highly indicative of extrahepatic biliary obstruction.
对81例LP-X阳性的不同肝脏疾病患者进行了胆汁淤积性异常血浆脂蛋白LP-X的定量测定。肝内胆汁淤积患者（急性肝炎、中毒性肝炎、原发性胆汁性肝硬化和胆管炎）45例以及肝外胆汁淤积患者（肿瘤和胆总管结石引起的肝外胆管梗阻）36例，其血浆LP-X浓度均有很大差异。肝外胆汁淤积患者的血浆LP-X浓度（中位数158mg/100ml）显著高于肝内胆汁淤积患者（中位数25mg/100ml）（P小于0.001）。42%的肝外胆管梗阻患者和33%的肝外胆管梗阻患者的LP-X水平超过400mg/100ml。LP-X的血浆浓度与碱性磷酸酶的血浆活性和血清胆红素显著相关，但在区分肝内和肝外胆汁淤积方面似乎优于这两个参数。血浆LP-X水平高于400mg/100ml高度提示肝外胆管梗阻。
