Vesin P, Cattan D
Sem Hop. 1975 Mar 8;51(12):817-21.
The authors report 4 cases of carcinoma of the intestine, stomach, ovary and breast, association with monoclonal Ig. Clinical and laboratory analysis showed, in particular, that the immunoglobulin was present in small quantity and that there was no Bence-Jones protein in these 4 cases, that the bone marrow was little, or practically unmodified. The authors then discuss the nature, whether by chance or not, of this association the differential diagnosis with major monoclonal dysglobulinemia, e.g. myeloma or Waldenström's disease, and the significance in a cancer patient, of the discovery of Igmc. According to the authors, although in a few cases the tumour may induce development of a clone secreting Igmc, usually carcinoma and Igmc are independent from one another and are due to a common mechanism : reduction in cell immunity, according to Burnet.
作者报告了4例分别发生于肠道、胃、卵巢和乳腺的癌，伴有单克隆免疫球蛋白。临床和实验室分析特别显示，这4例中免疫球蛋白含量少，且无本周氏蛋白，骨髓几乎未受影响或实际上未改变。作者接着讨论了这种关联的性质（无论是否偶然）、与主要单克隆球蛋白血症（如骨髓瘤或瓦尔登斯特伦病）的鉴别诊断，以及在癌症患者中发现免疫球蛋白M克隆的意义。据作者称，虽然在少数情况下肿瘤可能诱导分泌免疫球蛋白M克隆的发育，但通常癌和免疫球蛋白M克隆彼此独立，且是由一个共同机制导致的：根据伯内特的理论，是细胞免疫降低。
