Anlar F Y, Kabasakal E, Karşi R
Department of Pediatrics/Allergy, Ondokuz Mayis University, Samsun, Turkey.
Respir Med. 2006 Sep;100(9):1647-50. doi: 10.1016/j.rmed.2006.01.003. Epub 2006 Feb 15.
Atopy is expected to be less frequent and milder in patients with early exposure to bacterial infections because of regulatory immune mechanisms. The definition of the hygiene hypothesis and most of the related studies have been performed in children. In a population where both tuberculosis (tbc) and atopy are prevalent, we investigated skin test results to allergens in adults with tbc. A standard panel of skin-prick tests (SPTs) was applied to patients with active (n = 21) or inactive (n = 72) tbc and age-matched healthy control subjects (n = 76) from the same environment. Patients also had tuberculin skin tests applied twice at 8 weeks' interval. Patients with inactive tbc had a higher rate of allergic symptoms than those with active tbc (P < 0.01). SPTs were less frequently positive in tbc patients than in control subjects (P < 0.005). Tuberculin skin reactions were not related to SPTs positivity. Our results suggest allergic skin test reactions may be suppressed in patients with tbc: the interpretation of SPTs should be made accordingly.
由于免疫调节机制，预计早期接触细菌感染的患者特应性的发生率较低且症状较轻。卫生假说的定义及大多数相关研究都是在儿童中进行的。在结核病（tbc）和特应性都很普遍的人群中，我们调查了患有tbc的成年人对过敏原的皮肤试验结果。对来自同一环境的活动性tbc患者（n = 21）或非活动性tbc患者（n = 72）以及年龄匹配的健康对照者（n = 76）进行了标准的皮肤点刺试验（SPT）。患者还每隔8周进行两次结核菌素皮肤试验。非活动性tbc患者的过敏症状发生率高于活动性tbc患者（P < 0.01）。tbc患者的SPT阳性率低于对照者（P < 0.005）。结核菌素皮肤反应与SPT阳性无关。我们的结果表明，tbc患者的过敏性皮肤试验反应可能受到抑制：应据此对SPT结果进行解读。
