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Variability in the P6gag domains of HIV-1 involved in viral budding.

作者信息

Holguín Africa, Alvarez Amparo, Soriano Vincent

机构信息

Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

出版信息

AIDS. 2006 Feb 28;20(4):624-7. doi: 10.1097/01.aids.0000210619.75707.21.

DOI:10.1097/01.aids.0000210619.75707.21
PMID:16470130
Abstract

The genetic variability within PT/SAP, LYP and LXXLF HIV-1 P6gag motifs, required for the binding to Tsg101 and AIP1 cellular host proteins during viral budding, was examined in 122 HIV-infected subjects. PT/SAP duplications were statistically more frequent in B versus non-B subtypes. Substitutions at LYP were fourfold less frequent in antiretroviral-experienced only in clade B. P6gag variability across HIV-1 subtypes and after antiretroviral exposure may influence interactions with host cells involved in viral budding.

摘要

相似文献

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