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环甲膜上喉切除术联合环舌会厌固定术治疗晚期声门癌

Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer.

作者信息

Lima Roberto A, Freitas Emilson Q, Dias Fernando L, Barbosa Mauro M, Kligerman Jacob, Soares Jose R, Santos Izabella C, Rocha Ricardo M, Cernea Claudio R

机构信息

Head and Neck Surgery Service, Brazilian National Cancer Institute/INCA, Avenida Armando Lombardi, 1000 Bloco 2/107, Barra, 22640-000, Rio de Janeiro, RJ, Brazil.

出版信息

Head Neck. 2006 Jun;28(6):481-6. doi: 10.1002/hed.20361.

Abstract

BACKGROUND

Supracricoid laryngectomy with cri-cohyoidoepiglottopexy (CHEP) is a conservative surgical procedure indicated in selected cases of advanced glottic carcinoma.

METHODS

This study is a review of our experience with 43 patients with T3/T4 glottic squamous cell carcinoma who underwent CHEP in our institution. All but two patients underwent selective neck dissections. All patients were staged on the basis of the 2002 TNM classification. Rates of recurrence and death were estimated by the Kaplan-Meier method.

RESULTS

The 5-year disease-specific survival and 5-year relapse-free survival rates were 78% and 83%, respectively. Neck metastases were found in three patients. Cartilage invasion occurred in 11 cases. The average length of hospital stay was 5.7 days. The mean time of enteral feeding tube was 33.8 days, and the mean time for tracheotomy was 29.6 days. Overall, normal swallowing was achieved in 74.4% of patients. Eleven patients had mild and major complications. Laryngeal stenosis emerged as the most frequent major complication. Three patients (6.9%) had local recurrences. Two patients (4.6%) had neck metastases.

CONCLUSIONS

On the basis of this study, over a 7-year period with 43 patients with advanced glottic cancer, a successful on-cologic outcome is confirmed.

摘要

背景

环状软骨上喉切除术联合环状软骨-舌骨-会厌固定术(CHEP)是一种针对特定晚期声门癌病例的保守性外科手术。

方法

本研究回顾了我院43例接受CHEP的T3/T4期声门鳞状细胞癌患者的治疗经验。除2例患者外,其余均接受了选择性颈部清扫术。所有患者均根据2002年TNM分类进行分期。采用Kaplan-Meier法估计复发率和死亡率。

结果

5年疾病特异性生存率和5年无复发生存率分别为78%和83%。3例患者出现颈部转移。11例发生软骨侵犯。平均住院时间为5.7天。肠内喂养管平均留置时间为33.8天,气管切开平均时间为29.6天。总体而言,74.4%的患者实现了正常吞咽。11例患者出现轻度和重度并发症。喉狭窄是最常见的重度并发症。3例患者(6.9%)出现局部复发。2例患者(4.6%)出现颈部转移。

结论

基于本研究,在7年时间里对43例晚期声门癌患者进行治疗,证实了肿瘤学治疗结果是成功的。

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