左旋布比卡因与消旋布比卡因用于剖宫产硬膜外麻醉的比较。

Levobupivacaine versus racemic bupivacaine for extradural anesthesia for cesarean delivery.

作者信息

Ngamprasertwong Pornswan, Udomtecha Danai, Charuluxananan Somrat, Rodanant Oraluxana, Srihatajati Chaiwat, Baogham Sintichai

机构信息

Department of Anesthesiology and Clinical Epidemiology Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Med Assoc Thai. 2005 Nov;88(11):1563-8.

PMID:16471103

Abstract

BACKGROUND AND OBJECTIVES

Bupivacaine is available as a racemic mixture of dextrobupivacaine and levobupivacaine. Many studies show that dextrobupivacaine has a greater inherent central nervous system and cardiovascular toxicity than levobupivacaine. The aim of the present study was to investigate the clinical efficacy and safety of levobupivacaine compared with racemic bupivacaine for extradural anesthesia. METERIAL AND METHOD: The authors studied 61 patients undergoing elective cesarean delivery who received either 0.5% levobupivacaine (n = 31) or 0.5% bupivacaine (n = 30) extradurally, in a randomized, double blind study.

RESULTS

The 2 groups were similar in terms of time to block suitable for surgery, duration of sensory block, time to T10 regression, time to onset and offset of motor block, verbal numeric pain scores at abdominal opening and at child birth. Mean (SD) dose of 0.5% levobupivacaine and 0.5% bupivacaine were 19.3 (4.6) ml and 17.3 (3.8) ml respectively, p = 0.069.

CONCLUSION

Levobupivacaine produces an extradural block that is similar to bupivacaine, and is an alternative to bupivacaine for cesarean delivery patients.

摘要

背景与目的

布比卡因是以右旋布比卡因和左旋布比卡因的消旋混合物形式存在。许多研究表明，右旋布比卡因比左旋布比卡因具有更大的固有中枢神经系统和心血管毒性。本研究的目的是调查与消旋布比卡因相比，左旋布比卡因用于硬膜外麻醉的临床疗效和安全性。材料与方法：作者在一项随机、双盲研究中，研究了61例行择期剖宫产的患者，这些患者硬膜外分别接受0.5%左旋布比卡因（n = 31）或0.5%布比卡因（n = 30）。