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左旋布比卡因:在局部麻醉和疼痛管理中的应用综述。

Levobupivacaine: a review of its use in regional anaesthesia and pain management.

机构信息

Adis, Auckland, New Zealand.

出版信息

Drugs. 2010 Apr 16;70(6):761-91. doi: 10.2165/11203250-000000000-00000.

DOI:10.2165/11203250-000000000-00000
PMID:20394458
Abstract

Levobupivacaine (Chirocaine) is a long-acting amide local anaesthetic that is effective when administered as an epidural, spinal, peripheral nerve or ocular block, or by topical application or local infiltration. In comparative trials, its clinical effects were not generally significantly different from those of bupivacaine or ropivacaine, although there was some variability in efficacy findings in different clinical populations. Levobupivacaine was generally well tolerated. Levobupivacaine provides effective anaesthesia and analgesia for a wide range of clinical populations and is a useful alternative to bupivacaine.

摘要

左旋布比卡因(赛罗卡因)是一种长效酰胺类局部麻醉剂,作为硬膜外、脊髓、周围神经或眼部阻滞,或通过局部应用或局部浸润给药时有效。在对照试验中,其临床效果通常与布比卡因或罗哌卡因无显著差异,尽管在不同的临床人群中疗效发现存在一定的变异性。左旋布比卡因通常具有良好的耐受性。左旋布比卡因可为广泛的临床人群提供有效的麻醉和镇痛,是布比卡因的有用替代品。

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Comparison of 0.25% levobupivacaine and 0.25% bupivacaine for posterior approach interscalene brachial plexus block.0.25% 左旋布比卡因与 0.25% 布比卡因用于后路肌间沟臂丛神经阻滞的比较。
J Anesth. 2010 Feb;24(1):38-42. doi: 10.1007/s00540-009-0846-0.
2
The median effective dose of bupivacaine, levobupivacaine, and ropivacaine after intrathecal injection in lower limb surgery.布比卡因、左旋布比卡因和罗哌卡因在下肢手术中鞘内注射后的半数有效剂量。
Anesth Analg. 2009 Oct;109(4):1331-4. doi: 10.1213/ane.0b013e3181b1912b.
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Low-dose epidural top up for emergency caesarean delivery: a randomised comparison of levobupivacaine versus lidocaine/epinephrine/fentanyl.
硬膜外技术与腋中线超声引导 TAP 阻滞用于腹腔镜根治性前列腺切除术术后镇痛的比较:一项准随机临床试验。
Braz J Anesthesiol. 2022 Mar-Apr;72(2):253-260. doi: 10.1016/j.bjane.2021.03.021. Epub 2021 Apr 26.
4
Levobupivacaine-Loaded Liposome Associated with Thermogel for Prolonged Analgesia.载布比卡因脂质体与热凝胶联合用于延长镇痛。
AAPS PharmSciTech. 2021 Mar 14;22(3):104. doi: 10.1208/s12249-021-01942-x.
5
Pruritus after continuous administration of epidural morphine for post-cesarean delivery analgesia: a case control study.连续硬膜外吗啡用于剖宫产术后镇痛后瘙痒:病例对照研究。
BMC Pregnancy Childbirth. 2021 Jan 15;21(1):60. doi: 10.1186/s12884-020-03522-6.
6
Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.左旋布比卡因的临床药代动力学与药效学
Clin Pharmacokinet. 2020 Jun;59(6):715-745. doi: 10.1007/s40262-020-00868-0.
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Safety and Pharmacokinetics of Levobupivacaine Following Fascia Iliaca Compartment Block in Elderly Patients.老年患者股外侧肌间隙阻滞时左旋布比卡因的安全性和药代动力学。
Drugs Aging. 2019 Jun;36(6):541-548. doi: 10.1007/s40266-019-00652-1.
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Investigation into spinal anesthetic failure with hyperbaric bupivacaine: the role of cold exposure on bupivacaine degradation.研究高压布比卡因椎管内麻醉失败:冷暴露对布比卡因降解的作用。
Can J Anaesth. 2019 Jul;66(7):803-812. doi: 10.1007/s12630-019-01343-6. Epub 2019 Mar 15.
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A Comparison of Three Different Volumes of Levobupivacaine for Caudal Block in Children Undergoing Orchidopexy and Inguinal Hernia Repair.左旋布比卡因用于小儿隐睾固定术和腹股沟疝修补术的三种不同容量骶管阻滞的比较。
Med Princ Pract. 2017;26(4):331-336. doi: 10.1159/000475936. Epub 2017 Apr 23.
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Ropivacaine versus levobupivacaine in peripheral nerve block: A PRISMA-compliant meta-analysis of randomized controlled trials.罗哌卡因与左旋布比卡因用于外周神经阻滞:一项符合PRISMA标准的随机对照试验的荟萃分析。
Medicine (Baltimore). 2017 Apr;96(14):e6551. doi: 10.1097/MD.0000000000006551.
低剂量硬膜外追加用于急诊剖宫产:左旋布比卡因与利多卡因/肾上腺素/芬太尼的随机对照比较
Int J Obstet Anesth. 2009 Oct;18(4):335-41. doi: 10.1016/j.ijoa.2009.03.011. Epub 2009 Sep 3.
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Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required.在左旋布比卡因或罗哌卡因鞘内麻醉中添加舒芬太尼会影响所需的最小局部麻醉剂量。
Acta Anaesthesiol Scand. 2009 Oct;53(9):1214-20. doi: 10.1111/j.1399-6576.2009.02033.x. Epub 2009 Jul 22.
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Comparison of 0.5% levobupivacaine, 0.5% bupivacaine, and 2% lidocaine for retrobulbar anesthesia in vitreoretinal surgery.0.5%左旋布比卡因、0.5%布比卡因和2%利多卡因用于玻璃体视网膜手术球后麻醉的比较。
Eur J Ophthalmol. 2009 Mar-Apr;19(2):280-4. doi: 10.1177/112067210901900217.
6
Comparative study of topical anaesthesia with lidocaine 2% vs levobupivacaine 0.75% in cataract surgery.白内障手术中2%利多卡因与0.75%左旋布比卡因局部麻醉的比较研究
Br J Anaesth. 2009 Feb;102(2):216-20. doi: 10.1093/bja/aen369.
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The optimum concentration of levobupivacaine for intra-operative caudal analgesia in children undergoing inguinal hernia repair at equal volumes of injectate.在注射量相同的情况下,左旋布比卡因用于小儿腹股沟疝修补术中骶管内术中镇痛的最佳浓度。
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Anaesth Intensive Care. 2008 Sep;36(5):659-64. doi: 10.1177/0310057X0803600505.
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The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine.局部麻醉药的毒性:罗哌卡因和左旋布比卡因的地位。
Curr Opin Anaesthesiol. 2008 Oct;21(5):645-50. doi: 10.1097/ACO.0b013e32830c214c.